Evaluation of Lymphoma Prognosis and Survivorship in Recently Diagnosed Patients, LEO Study

Enrolling by invitation

Conditions studied: Lymphoma, Non-Hodgkin

In brief

The goal of this infrastructure protocol is to build and maintain a large and diverse observational cohort study to support broad and cutting-edge research focused on NHL prognosis and survivorship. The LEO cohort will promote identification of clinical (including co-morbid diseases), epidemiologic (including lifestyle and other exposures), host genetic, tumor, and treatment factors that impact multiple outcomes (including event-free, overall and lymphoma-specific survival; new onset comorbidities; and patient-reported outcomes). This resource also will allow examination of the interaction among these factors in order to better understand the clinical and molecular epidemiology of outcomes in NHL. Ultimately, this approach will drive discovery and validation of treatment endpoints, improve prognostication, and identify novel approaches to improve short and long-term outcomes for NHL patients.

Key facts

Study ID

NCT04996706

Run by

Mayo Clinic

People needed

21000

Starts

2021-08-16

Expected to finish

2031-03-31

Last updated by the study team

2026-07-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Newly diagnosed within 6 months (180 days) of enrollment
• Patients may have been treated as long as initial non-Hodgkins Lymphoma (NHL) or Hodgkin's Lymphoma (HL) diagnosis is within 6 months of enrollment
• 18 years of age or older

You may not qualify if…

• Does not meet inclusion criteria

Where it is running

• Mayo Clinic in Arizona — Scottsdale, Arizona, United States
• Mayo Clinic in Florida — Jacksonville, Florida, United States
• University of Miami: Sylvester Comprehensive Cancer Center — Miami, Florida, United States
• Emory University Hospital Midtown — Atlanta, Georgia, United States
• Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
• Emory St. Joseph's Hospital — Atlanta, Georgia, United States
• University of Iowa — Iowa City, Iowa, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Washington University School of Medicine in St. Louis — St Louis, Missouri, United States
• Weill Cornell Medical College — New York, New York, United States
• University of Rochester Medical Center — Rochester, New York, United States
• MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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