APOE in the Predisposition to, Protection From, and Prevention of Alzheimer's Disease
Enrolling by invitation
Conditions studied: Alzheimer Disease
In brief
The purpose of this study is to track changes in the brain related to Alzheimer's disease. The results from this study will be used to develop new approaches to prevent or delay the onset of memory and thinking problems associated with Alzheimer's.
Key facts
- Study ID
- NCT04994847
- Run by
- Banner Health
- People needed
- 300
- Starts
- 2021-05-01
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2025-07-20
Who can join
Age: 50 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Male or female age 50 to 90 years old in good general health with no diseases expected to interfere with the study.
- Willing to undergo health and cognitive assessments, brain imaging sessions (MRI and PET), and collection and banking of blood with venipuncture and CSF by lumbar puncture for genetic research, biomarker research, and DNA banking.
- Determined to be cognitively unimpaired by PI (mechanisms may include verbal interview, participant or study partner reports or specific scores on cognitive assessments)
You may not qualify if…
- Participants with significant health issues or medical diseases that may interfere with participation, including infectious diseases that pose a risk to study personnel.
- For PET or MRI: Female participant who is pregnant, lactating, or of childbearing potential without a negative pregnancy test or being two years postmenopausal or surgically sterile.
- For MRI: Any contraindication for MRI including, but not limited to, pacemaker, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin, or body.
- For CSF collection: Medical or surgical contraindication for lumbar puncture (e.g. on anti-coagulant therapy or had prior lumbar spinal surgery).
Where it is running
- Banner Alzheimer's Institute — Phoenix, Arizona, United States
Full record on ClinicalTrials.gov
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