Diagnostic and Prognostic Biomarkers for High-impact Chronic Pain: Development and Validation

Running, not enrolling

Conditions studied: Chronic Musculoskeletal Pain, Pain, Pain, Chronic, Joint Pain

In brief

To identify diagnostic and prognostic biomarker signatures of recovery versus having persisting high-impact chronic pain and functional disability in adults with Chronic Musculoskeletal Pain.

Key facts

Study ID

NCT04994249

Run by

Stanford University

People needed

250

Starts

2022-03-21

Expected to finish

2027-12-31

Last updated by the study team

2026-02-20

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1) Inclusion criteria: Adults (18-80 years; \~64% female expected based on clinic distribution) with chronic MSP as categorized by the World Health Organization (WHO).

You may not qualify if…

• 1) Chronic musculoskeletal pain (MSP) explained by inflammatory disease (e.g., rheumatoid arthritis, lupus) or CP with a primary diagnosis other than chronic MSP (e.g., neuropathic pain), (2) significant cognitive impairment, (3) MRI contraindication, (4) medical or psychiatric problems interfering with the study, (5) current medicolegal factors (e.g., open disability claim), (6) plans for surgery during the study, (7) pregnancy and (8) Children under the age of 18 will not be included in the study.

Where it is running

• Stanford University — Palo Alto, California, United States

Full record on ClinicalTrials.gov

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