Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children

Recruiting now

Conditions studied: Survivors of Childhood Cancer, Bladder Dysfunction

In brief

The over-arching aim of this study is to evaluate the effects of two specific anti-cancer chemotherapies, vincristine and doxorubicin, on bladder function and urine composition.

Key facts

Study ID

NCT04993859

Run by

University of Colorado, Denver

People needed

152

Starts

2021-06-02

Expected to finish

2026-07-09

Last updated by the study team

2025-10-15

Who can join

Age: 5 and older, up to 13. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children aged 5-13 years old
• A history of cancer
• Treatment with a chemotherapy regimen including VCR and/or DOX
• Completion of chemotherapy at least one year prior to study enrollment and survey completion.

You may not qualify if…

• Patients with a:
• Primary pelvic tumor
• Pelvic irradiation
• Pre-existing bladder/bowel dysfunction
• Spinal defects
• Neurologic disorder
• Neuro-oncologic tumor or brain metastasis
• Cyclophosphamide or ifosfamide therapy

Where it is running

• Children's Hospital Colorado — Aurora, Colorado, United States (enrolling)

Full record on ClinicalTrials.gov

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