Postcapillary Blood Gas Analysis in Wedge Position (Wedge-BGA)

Recruiting now

Conditions studied: Pulmonary Hypertension

In brief

If pulmonary hypertension is suspected, a right heart catheterization is usually performed to confirm or rule out the diagnosis. As part of this examination, blood samples are taken from various locations as standard and blood gas analyses are performed. One of the most important measurements during the right heart catheterization is the measurement of the pulmonary arterial occlusion pressure by the so-called wedge maneuver. To measure this value, the catheter with inflated balloon must be advanced into the pulmonary vessels until the "wedge" position is reached, i.e. the balloon completely occludes a branch of the pulmonary artery. In this study, the investigators want to characterize patients with pulmonary hypertension of different causes in more detail. To do that, two blood samples (totaling approximately 4 mL of blood, one sample directly after occlusion and the other one two minutes later) will be drawn during the right heart catheterization from the above-mentioned "wedge" position", behind the inflated balloon, and blood gas analyses will be performed on these samples. In addition, various clinical parameters (comorbidities, etc.) will be recorded by means of clinical questionnaires. Follow-up data will be analyzed and correlations with the aforementioned blood gas analyses will be examined. The results of the study will be used to more precisely characterize the still vague concept of secondary pulmonary hypertension. This could help to develop new therapeutic strategies in some subgroups in the future.

Key facts

Study ID

NCT04993612

Run by

Ayham Daher

People needed

100

Starts

2021-06-25

Expected to finish

2026-06-30

Last updated by the study team

2026-02-06

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who have a clearly defined indication for Right heart catheterization.
• Age > 18 years
• Informed consent for participation in the study will sign

You may not qualify if…

• Individuals who are not fully capable of giving consent and understanding the nature, significance, and scope of the study
• Pregnancy and lactation
• Wedge-BGA not possible

Where it is running

• University Hospital RWTH Aachen — Aachen, Germany (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.