Cardiac Magnetic Resonance for Risk Stratification in Dilated Cardiomyopathy

Recruiting now

Conditions studied: Dilated Cardiomyopathy, Single-center Study

In brief

Dilated cardiomyopathy (DCM) is an increasingly recognized cause of morbidity and mortality with heterogenous etiologies (eg, genetic, environment) and clinical manifestations, characterized by left ventricular (LV) systolic dysfunction and LV or biventricular dilation. Previous publications reported the three-year treated mortality rates remain high at 12%-20% and a reported 5-year mortality rate up to 50%, with death resulting from ventricular arrhythmia leading to sudden cardiac death (SCD) or advanced heart failure (HF). With large fields of view and high spatial resolution, Cardiac magnetic resonance (CMR) is the reference standard for assessing cardiac mass, volume, and function. CMR also provides non noninvasive characterization of the myocardium benefiting to differential diagnosis and risk stratification.

Key facts

Study ID

NCT04990297

Run by

Chinese Academy of Medical Sciences, Fuwai Hospital

People needed

2500

Starts

2019-12-24

Expected to finish

2031-12-31

Last updated by the study team

2022-10-31

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• reduced left ventricular ejection fraction (LVEF<50%)
• LV end-diastolic volume >2SD from normal according to normograms corrected by body surface area (BSA) and age.

You may not qualify if…

• Any evidence indicating the presence of ischemic heart disease:
• Coronary angiography, perfusion imaging Medical documentation that indicated the presence of ischemic heart disease An infarct pattern of late gadolinium enhancement on cardiac magnetic resonance studies and/or acute coronary syndrome or coronary revascularization during follow-up
• Any evidence of hypertrophic cardiomyopathy, or moderate-to-severe valvular disease[18], or infiltrative disease (such as amyloidosis, sarcoidosis, Fabry disease)
• Incessant arrhythmias
• Inability to lie flat
• Pregnancy
• Contraindication to cardiac magnetic resonance including severe claustrophobia, defibrillators, pacemakers, certain types of intracranial aneurysm clips, intraocular metal, and Stage IV/V chronic kidney disease
• Diabetes mellitus with end organ damage
• Inability to provide informed consent.

Where it is running

• Fuwai Hospital — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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