Brain and Behavior Correlates of Arm Rehabilitation

Completed · Not applicable

Conditions studied: Stroke, Cardiovascular

In brief

This project is designed to use three-dimensional movement analysis and magnetic resonance (fMRI) neuroimaging techniques to examine the brain activity and motor behavior changes associated with constraint-induced (CI) therapy for patients with sub-acute stroke (3-9 months post-stroke).Participants are evaluated at 5 time points-1-mo (pre \& post), 6-mo (pre \& post), and 12-mo. Each person is randomized to receive CI therapy either between pre- and post-evaluations or after the 6-mo pre-evaluation. We will determine the effects of CI therapy on 1) reaching and grasping actions using behavioral kinematics and 2) the sensorimotor network through fMRI scans with goal-directed aiming and grasping tasks. We will also determine the relationship between lesion size and location using 3-D volumetric MRI scans and behavioral outcomes as a consequence of CI therapy.

Key facts

Study ID

NCT04989920

Run by

University of Southern California

People needed

23

Starts

2003-04-28

Expected to finish

2011-07-15

Last updated by the study team

2021-08-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1. 3 - 9 months post first-time stroke of infarct hemorrhagic type at the beginning of participation.
• over the age of 18 years with no upper age limit.
• cleared by a medical physician to participate.
• Independent in basic activities of living.
• minimum motor criteria: at least 10 degrees of active wrist extension, 10 degrees of finger extension in at least two fingers and the thumb (abduction) and the elbow (90 degrees flexion and extension) and shoulder (45 degrees flexion and abduction motion criteria.

You may not qualify if…

• 1. score below 24 on the Folstein Mini-mental status exam (MMSE)
• score greater than an average of 2.5 on the Motor Activity Log (MAL) amount scale
• are concurrently participating in any experimental drug study
• are concurrently participating in any formal physical rehabilitation or clinical trials
• do not meet the minimum motor criteria or who do not meet the minimum balance criteria.
• pre-menopausal woman who is pregnant

Where it is running

• University of Southern California — Los Angeles, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.