Transcatheter Aortic Valve Replacement (TAVR) Effects on Cardiac Conduction System

Completed

Conditions studied: Aortic Stenosis, Transcatheter Aortic Valve Replacement, Heart Block

In brief

This is a prospective observational study, the purpose of which is to: 1. Characterize response of the AV conduction system to TAVR with various prostheses by recording continuous His bundle electrograms during valve placement. 2. Correlate preprocedure ECG features with changes in AV nodal and infranodal conduction during placement of the valve prosthesis. 3. Correlate changes in AV nodal and infranodal conduction during the procedure with risk of developing AV conduction block after TAVR. 4. Assess the contribution of stressing the conduction system by atrial pacing prior to and following TAVR to prediction of postprocedural heart block. Assess the correlation between new onset bundle branch block, site and degree of conduction block or delay and subsequent development of high-grade or complete AV block.

Key facts

Study ID
NCT04982406
Run by
Beth Israel Deaconess Medical Center
People needed
409
Starts
2021-05-18
Expected to finish
2025-01-21
Last updated by the study team
2025-01-24

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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