BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)

Running, not enrolling

Conditions studied: Primary Hyperoxaluria Type 1

In brief

The purpose of this study is to describe the natural history and progression of patients diagnosed with PH1, and to characterize the long-term real-world safety and effectiveness of lumasiran.

Key facts

Study ID

NCT04982393

Run by

Alnylam Pharmaceuticals

People needed

207

Starts

2021-12-13

Expected to finish

2028-09-01

Last updated by the study team

2026-04-24

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Documented diagnosis of PH1, per physician's determination

You may not qualify if…

• Currently enrolled in a clinical trial for any investigational agent

Where it is running

• Clinical Trial Site — Phoenix, Arizona, United States
• Clinical Trial Site — Washington D.C., District of Columbia, United States
• Clinical Trial Site — Boston, Massachusetts, United States
• Clinical Trial Site — Rochester, Minnesota, United States
• Clinical Trial Site — Cincinnati, Ohio, United States
• Clinical Trial Site — Pittsburgh, Pennsylvania, United States
• Clinical Trial Site — Dallas, Texas, United States
• Clinical Trial Site — Houston, Texas, United States
• Clinical Trial Site — Ghent, Belgium
• Clinical Trial Site — Liège, Belgium
• Clinical Trial Site — Hamilton, Ontario, Canada
• Clinical Trial Site — Toronto, Ontario, Canada
• Clinical Trial Site — Laurier, Quebec, Canada
• Clinical Trial Site — Bordeaux, France
• Clinical Trial Site — Lyon, France
• Clinical Trial Site — Paris, France
• Clinical Trial Site — Berlin, Germany
• Clinical Trial Site — Cologne, Germany
• Clinical Trial Site — Hamburg, Germany
• Clinical Trial Site — Jerusalem, Israel
• Clinical Trial Site — Orbassano, Torino, Italy
• Clinical Trial Site — Milan, Italy
• Clinical Trial Site — Verona, Italy
• Clinical Trial Site — Amsterdam, Netherlands
• Clinical Trial Site — Santa Cruz de Tenerife, Canary Islands, Spain

Full record on ClinicalTrials.gov

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