Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
Recruiting now
Conditions studied: Solid Tumor, Adult, Colorectal Cancer, Non Small Cell Lung Cancer, Pancreatic Cancer, CRC, NSCLC, Pancreas Cancer, Mesothelioma, Ovarian Cancer, Ovarian Neoplasms, Ovarian Carcinoma, Mesothelioma, Malignant, Mesothelioma; Lung, Cancer, Triple Negative Breast Cancer (TNBC), Renal Cell Carcinoma (Kidney Cancer), Head and Neck Squamous Cell Carcinoma HNSCC
In brief
Objective: To collect information on how often a solid tumor cancer might lose the Human Leukocyte Antigen (HLA) by next generation sequencing and perform apheresis to collect and store an eligible participant's own T cells for future use to make CAR T-Cell therapy for their disease treatment. Design: This is a non-interventional, observational study to evaluate participants with solid tumors with a high risk of relapse for incurable disease. No interventional therapy will be administered on this study. Some of the information regarding the participant's tumor analysis may be beneficial to management of their disease. Participants that meet all criteria may be enrolled and leukapheresed (blood cells collected). The participant's cells will be processed and stored for potential manufacture of CAR T-cell therapy upon relapse of their cancer.
Key facts
- Study ID
- NCT04981119
- Run by
- A2 Biotherapeutics Inc.
- People needed
- 200
- Starts
- 2021-10-29
- Expected to finish
- 2029-04-01
- Last updated by the study team
- 2026-06-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Banner Health — Gilbert, Arizona, United States (enrolling)
- Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)
- Fred Hutchinson Cancer Center — Seattle, Washington, United States (enrolling)
- Mayo Clinic Hospital — Phoenix, Arizona, United States (enrolling)
- University of California San Diego — La Jolla, California, United States (enrolling)
- Stanford University — Palo Alto, California, United States (enrolling)
- UCLA Medical Center — Santa Monica, California, United States (enrolling)
- Mayo Clinic Jacksonville — Jacksonville, Florida, United States (enrolling)
- Moffitt Cancer Center — Tampa, Florida, United States (enrolling)
- Mayo Clinic Rochester — Rochester, Minnesota, United States (enrolling)
- Washington University — St Louis, Missouri, United States (enrolling)
- NYU Langone Medical Center — New York, New York, United States (enrolling)
- The Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States (enrolling)
- City of Hope — Duarte, California, United States
- MD Anderson Cancer Center — Houston, Texas, United States
- Massachusetts General Hospital/Dana Farber Cancer Institute — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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