Function of Circulating Exosomes in Sepsis-induced Immunosuppression

Status unconfirmed

Conditions studied: Sepsis, Septic Shock, Sepsis Syndrome, Sepsis Bacterial, Sepsis, Severe, Sepsis Bacteremia

In brief

This is a single-center prospective bio-specimen analysis and observational study aiming to define immune pathways disrupted in bacterial sepsis and to identify clinically useful biomarkers of immune status.

Key facts

Study ID

NCT04979767

Run by

University of Kansas Medical Center

People needed

80

Starts

2021-04-15

Expected to finish

2022-06-30

Last updated by the study team

2021-07-28

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥ 50 years with ≥ 2 chronic comorbidities
• Highly suspected bacterial infection based on clinical or radiologic evidence
• ≥ 2 systemic inflammatory response syndrome (SIRS) criteria
• Actual/anticipated admission to intensive care unit (ICU)
• Anticipated length of hospital stay ≥ 5 days

You may not qualify if…

• Pregnancy
• Underlying immunosuppression (solid organ transplant, hematopoietic stem cell transplant, neutropenia, HIV infection, long-term corticosteroid use (≥ 20 mg prednisone equivalents for ≥ 14 days), immunosuppressants, radiation, chemotherapy, immune-modifying biologics, viral hepatitis, or systemic autoimmune diseases)
• Current immunotherapy use
• Confirmed COVID-19 infection

Where it is running

• University of Kansas Medical Center — Kansas City, Kansas, United States (enrolling)

Full record on ClinicalTrials.gov

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