Vascular Events In Patients Undergoing Same-day Noncardiac Surgery (VALIANCE) Study

Recruiting now

Conditions studied: Preoperative Care, Surgery--Complications, Myocardial Infarction

In brief

The proportion of noncardiac surgeries performed as same-day surgery is increasing worldwide, with more complex surgeries being performed on higher risk patients in the outpatient setting. Little is known on the risk factors, incidence and prognosis of patients undergoing same-day noncardiac surgery. The main objective of this study is to inform on the incidence and risk factors of cardiovascular and other adverse events after same-day surgery and to develop risk prediction tools to better inform on the risk and selection of patients undergoing same-day surgery.

Key facts

Study ID

NCT04973397

Run by

Centre hospitalier de l'Université de Montréal (CHUM)

People needed

15000

Starts

2021-11-17

Expected to finish

2027-04-01

Last updated by the study team

2026-03-19

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 45-64 years of age with at least one risk factor, or ≥65 years of age;
• undergoing elective noncardiac same-day surgery;
• planned duration in the operating room 60 minutes or more;
• provided written consent.

You may not qualify if…

• intervention does not require the presence of an anesthesiologist;
• procedure is performed by a nonsurgical specialty (e.g., gastroenterology, pneumology, radio-oncology or radiology);
• intervention is an ophthalmologic procedure;
• previously enrolled in the VALIANCE study.

Where it is running

• Hospital Clinic Barcelona — Barcelona, Spain (enrolling)
• Cleveland Clinic Foundation Fairview Campus — Cleveland, Ohio, United States (enrolling)
• Cleveland Clinic Foundation Main Campus — Cleveland, Ohio, United States (enrolling)
• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
• Memorial Hermann Texas Medical Center UT Health — Houston, Texas, United States (enrolling)
• Maasstad Ziekenhuis Rotterdam — Rotterdam, Netherlands (enrolling)
• Wake Forest Baptist Medical Centre — Winston-Salem, North Carolina, United States (enrolling)
• Hamilton General Hospital — Hamilton, Ontario, Canada (enrolling)
• Juravinski Hospital and Cancer Centre — Hamilton, Ontario, Canada (enrolling)
• McMaster University Medical Centre — Hamilton, Ontario, Canada (enrolling)
• Mount Sinai Hospital — Toronto, Ontario, Canada (enrolling)
• Toronto Western Hospital — Toronto, Ontario, Canada (enrolling)
• St-Micheal's Hospital — Toronto, Ontario, Canada (enrolling)
• Centre Hospitalier de l'Université de Montréal (CHUM) — Montreal, Quebec, Canada (enrolling)
• St-Joseph's Healthcare Hamilton — Hamilton, Ontario, Canada
• Centre Hospitalier Universitaire de Sherbrooke — Sherbrooke, Quebec, Canada

Full record on ClinicalTrials.gov

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