Terbutaline Sulfate in Adults With Asthma

Withdrawn before enrolling · Phase 2/Phase 3

Conditions studied: Asthma

In brief

The overall aim in Part 1 is to compare the pharmacokinetic (PK)/pharmacodynamics (PD) relationship in intravenous (IV) versus subcutaneous (SQ) terbutaline sulfate to identify the optimal IV dosing range for use in Part 2. The overall aim in Part 2 is to evaluate the optimal IV dosing of terbutaline sulfate based on PD response and safety data.

Key facts

Study ID

NCT04973345

Run by

Kanecia Obie Zimmerman

People needed

0

Starts

2023-07-07

Expected to finish

2026-12-01

Last updated by the study team

2026-01-22

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participant has provided informed consent
• History of physician-diagnosed asthma
• Age ≥18 to <60 at time of consent
• Past (within 12 months of consent) or current (at screening visit)evidence of airway reactivity, defined as:
• Documentation of ≥10% FEV1 improvement following bronchodilator OR
• Positive methacholine challenge (20% or more FEV1 decrease at ≤ 16 mg/mL)
• Willing and able to undergo study procedures and attend required study visits.
• Adequate venous access for blood draws and drug administration, as determined by study investigator, or designee
• Weight ≥ 40kg
• FEV1 ≥ 60% predicted on day of terbutaline sulfate dosing
• Systolic blood pressure (BP) ≤ 150 millimeters of Mercury (mmHg) and diastolic BP ≤ 90 mmHg measured after 10 to 15 minutes of rest
• Heart rate > 45 and < 110 beats per minute (bpm) measured after 10 to 15 minutes of rest
• Female participants of child-bearing potential: negative pregnancy test (urine hCG) and agreement to use effective contraception (complete abstinence from vaginal intercourse, combination barrier and spermicide, partner vasectomy, bilateral tubal ligation, intrauterine device (IUD), progestin implants, or hormonal) during study participation

You may not qualify if…

• Self-reported pregnancy or lactating or breastfeeding
• Previous enrollment in the current study (any part)
• Any chronic respiratory condition besides asthma (including, but not limited to Chronic Obstructive Pulmonary Disease (COPD), emphysema, or interstitial lung disease) that in the opinion of the Principal Investigator (PI) or clinical site investigator, would make the participant unsuitable for the study
• Body Mass Index (BMI) > 35 kg/m2 (class II or III obesity)
• Moderate to severe renal impairment, defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2
• Self-reported combustible cigarette smoking of more than 1 pack per day.
• Greater than 20 pack-year smoking history
• Any history of cardiac disease (e.g. coronary insufficiency, cardiac arrhythmias), non-skin cancer, hyperthyroidism, diabetes mellitus type 1, uncontrolled diabetes mellitus type II (HbA1C>7.5 documented within past 12 months of screening) uncontrolled epilepsy (2 or more seizures within the past 12 months and not taking anti-seizure medication)
• History of ocular, brain, abdominal or thoracic surgery in the 12 months prior to screening
• Known hypersensitivity to terbutaline sulfate or albuterol
• Use of any medications from the following classes within 28 days prior to Visit 1: monoamine oxidase inhibitors, tricyclic antidepressants, beta blockers, non-potassium-sparing antihypertensive diuretics, or systemic corticosteroids
• Self-reported respiratory tract infection in the 14 days prior to Visit 1
• Any current chronic condition or past history of disease that, in the opinion of the PI would make the participant unsuitable for the study
• Baseline prolongation of QTc (QTc ≥ 460 ms by Fridericia's formula)
• Participation in another research study that includes use of any investigational drug treatment within the 30 days prior to Visit 1, or planned participation during the study period.

Where it is running

• University of Colorado — Aurora, Colorado, United States
• University of Vermont — Burlington, Vermont, United States

Full record on ClinicalTrials.gov

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