Using Nicotine to Reverse Age-related Auditory Processing Deficits
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Auditory Perceptual Impairment, Aging
In brief
The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety of patient populations and in healthy aging.
Key facts
- Study ID
- NCT04971954
- Run by
- University of California, Irvine
- People needed
- 48
- Starts
- 2022-02-01
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2026-03-27
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- between 18 and 85 years of age
- non-smokers with a score of 0-2 out of 10 maximum on the Fagerström index of smoking dependency
- cognitive performance within two standard deviations of the CERAD mean
You may not qualify if…
- less than 18 or greater than 85 years of age
- deafness or excessive hearing loss
- smokers with a score between 3 and 10 on the Fagerström index of smoking dependency
- history of psychiatric illness, neurological disorders, diabetes mellitus, renal failure, or cardiovascular disease
- regular use of prescription medications (excluding oral contraceptives)
- drug dependency
Where it is running
- Hearing and Speech Lab — Irvine, California, United States (enrolling)
Full record on ClinicalTrials.gov
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