Community Dynamics of Malaria Transmission in Humans and Mosquitoes at Maferinyah Sub-Prefecture, Guinea
Completed
Conditions studied: Malaria
In brief
Background: Half of the world s population is at risk of malaria. In 2015, there were 214 million cases of malaria and 438,000 deaths. A transmission-blocking vaccine (TBV) could help end the disease. Improved tests are needed to measure how well the vaccines work. Researchers want to collect data about malaria infection as the first step in testing a TBV in rural Guinea. Objective: To study community dynamics of malaria transmission by estimating the rate of blood smear positive people by month and season. Eligibility: People 6 months of age and older who live in Maf(SqrRoot)(Registered Trademark)rinyah sub-prefecture and plan to remain during the study. Households with at least 3 people who are eligible to take part in the study are also needed. Design: Participants will be screened with a medical and medicine history. They will have a physical exam. Their height and weight will be measured. Their vital signs may be taken. Participants will have a study visit each month for up to 3 years. They will get a study ID. They will be asked about any symptoms of malaria or changes in health. They will give blood samples. They may have a physical exam. Within 3 days of the study visits, live and dead mosquitoes may be gathered in and around their home. Insecticide spray will be used. Participants can visit the clinic at any time if they feel ill. If they have malaria, they will be treated according to Guinea National Malaria Control Guidelines for adults and children.
Key facts
- Study ID
- NCT04969913
- Run by
- National Institute of Allergy and Infectious Diseases (NIAID)
- People needed
- 400
- Starts
- 2022-03-07
- Expected to finish
- 2024-10-23
- Last updated by the study team
- 2024-10-24
Who can join
Age: 1 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- Immunology and Pathogenesis Laboratories — Bethesda, Maryland, United States
- Maferinyah Rural Health Training and Research Center — Maferinyah, Guinea
Full record on ClinicalTrials.gov
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