Metabolomic Impacts of Branched-chain Amino Acid Supplementation During Endurance Exercise

Completed · Not applicable · Has a placebo group

Conditions studied: Healthy

In brief

The overall goal of this investigation was to determine the impact of branch-chained amino acids (BCAAs) supplementation on serotonin and associated metabolites during endurance exercise on healthy individuals. Specifically, despite the strong theoretical basis for supplementation of BCAAs to attenuate serotonin production and fatigue during exercise, most human clinical trials have failed to demonstrate these benefits. To shed light on this discrepancy, the purpose of this study was to measure the impact of BCAA supplementation on serotonin and associated metabolites during exercise. To achieve this purpose, investigators determined the effects of the consumption of a BCAA beverage on endurance exercise performance and serum metabolites. The supplementation protocol consisted of two trials in which each participant consumed 8 grams of BCAA supplement in a beverage or a placebo in randomized order. It was hypothesized that post-exercise metabolites would differ between BCAA and placebo conditions.

Key facts

Study ID

NCT04969536

Run by

Montana State University

People needed

10

Starts

2019-10-01

Expected to finish

2021-02-23

Last updated by the study team

2023-05-03

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participate in at least 5 hours of cardiovascular activity per week

You may not qualify if…

• Any underlying injury
• The consumption of any selective serotonin re-uptake inhibitor (SSRI) medication

Where it is running

• Montana State University — Bozeman, Montana, United States

Full record on ClinicalTrials.gov

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