Countermeasures to Circadian Misalignment

Recruiting now · Not applicable

Conditions studied: Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity

In brief

Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.

Key facts

Study ID

NCT04966351

Run by

Colorado State University

People needed

32

Starts

2021-07-07

Expected to finish

2026-06-30

Last updated by the study team

2025-07-24

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-35 old; men and women; equal numbers of women and men will be included.
• Body Mass Index (BMI) between 20.0 and 24.9 ("normal" weight).
• Physical activity history: inactive to habitual moderate physical activity level
• Sleep/wake history: habitual sleep duration between 7-9.25 hours.
• Altitude history: Potential subjects must have lived at Denver altitude or higher for at least 3 months prior to inpatient stay.

You may not qualify if…

• Any clinically significant medical, psychiatric, or sleep disorder
• Use of prescribed medications/supplements/illicit drugs within one month prior to study
• History of shift work in year prior to study, or travel more than one time zone in three weeks prior to study. [NOTE: Subjects can be studied at a later date.]
• Women with history of prior gynecological pathology, <1 year post-partum, breast-feeding and/or pregnant.
• Non-English speakers will be excluded, as we do not have access to a translator who could rely accurate information to the participant for the consent or throughout the study.

Where it is running

• Colorado State University — Fort Collins, Colorado, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.