Neuraxial Labor Analgesia and Offspring Neurodevelopment

Recruiting now

Conditions studied: Pregnant Women, Labor Pain, Analgesia, Epidural, Infants, Neurodevelopmental Disorders

In brief

How perinatal factors affect the long-term development of children has always been an issue of much concern. This study is designed to explore the potential impact of maternal neuraxial labor analgesia exposure on offspring neurodevelopment.

Key facts

Study ID: NCT04964206
Run by: Dong-Xin Wang
People needed: 4645
Starts: 2022-10-14
Expected to finish: 2028-12-01
Last updated by the study team: 2026-06-09

Who can join

Age: 18 and older, up to 35. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Primiparae between 18 and 35 years of age with term single cephalic pregnancy;
Undergo regular prenatal examination in the study centers;
Preparing to deliver vaginally.

You may not qualify if…

History of psychiatric diseases (indicate those that are diagnosed before or during pregnancy by psychiatrists);
History of diseases involving the hypothalamic-pituitary-adrenal axis;
Presence of contraindications to epidural analgesia, which includes: (1) History of infectious disease of the central nervous system (poliomyelitis, cerebrospinal meningitis, encephalitis, etc.); (2) History of spinal or intra-spinal disease (trauma or surgery of spinal column, intra-spinal canal mass, etc.); (3) Systemic infection (sepsis); (4) Skin or soft tissue infection at the site of epidural puncture; (5) Coagulopathy.
Presence of contraindications to vaginal delivery;
Other reasons that are considered unsuitable for study participation.

Where it is running

Peking University First Hospital — Beijing, Beijing Municipality, China (enrolling)
Shenzhen Maternity and Child Healthcare Hospital — Shenzhen, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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