A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.

Recruiting now · Not applicable

Conditions studied: Aging, Cardiovascular Risk Factor

In brief

The ACTIONcardioRisk trial is designed to investigate the effect of aerobic and progressive resistance training exercises combined with cognitive training, on neurocognitive functioning of sedentary older adults with and without cardiovascular risk factors.

Key facts

Study ID

NCT04962061

Run by

Louis Bherer

People needed

159

Starts

2021-09-01

Expected to finish

2025-12-31

Last updated by the study team

2025-02-06

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult aged 60 and older,
• Normal or corrected vision and normal hearing for their age range,
• No cognitive impairment (Mini-Mental State Examination - MMSE ≥ 25),
• Inactive (< 150 min of physical activity per week).

You may not qualify if…

• MMSE ≤ 24 or diagnosis of dementia,
• Uncontrolled psychological / psychiatric condition within the past 6 months,
• Neurological disease,
• Severe exercise intolerance,
• Respiratory disease (e.g., asthma, COPD),
• Excessive alcohol consumption (> 15 drinks/week),
• Documented cerebral, peripheral or coronary atherosclerotic disease,
• Chronic systolic or diastolic heart failure,
• Symptomatic aortic stenosis,
• Atrial fibrillation,
• Automatic implantable defibrillator or permanent pacemaker,
• Malignant exertional arrhythmias,
• Non-cardiopulmonary limitation to exercise (e.g., arthritis).

Where it is running

• Preventive medicine and physical activity centre (centre EPIC), Montreal Heart Institute — Montreal, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

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