PK/PD of Ceftazidime Avitbatan Sodium in Children With Severe Infection

Recruiting now

Conditions studied: Sepsis, Antibiotic Reaction

In brief

Ceftazidime avitbatan sodium is a broad-spectrum antibiotic with an antimicrobial spectrum covering resistant gram-negative bacteria. Its use in pediatric intensive care for severe infections is not unusual. Pathophysiological changes in severe sepsis can lead to significant changes in pharmacokinetics and pharmacodynamics during continuous renal replacement therapy.This research aims to study change of pharmacokinetic and pharmacodynamic in severe infection children with extracorporeal life support, thus improve the treatment of severe sepsis and sepsis shock.

Key facts

Study ID

NCT04961580

Run by

Children's Hospital of Fudan University

People needed

30

Starts

2022-10-01

Expected to finish

2026-12-31

Last updated by the study team

2026-03-16

Who can join

Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children who are admitted in the pediatric intensive care unit receiving ceftazidime avitbatan sodium

You may not qualify if…

• No Informed Consent signed
• Participate in other clinical trials

Where it is running

• Children's hosptial of fudan university — Shanghai, Shanghai Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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