Study of an Environmental Risk Factor in Crohn's Disease
Recruiting now
Conditions studied: Inflammatory Bowel Diseases
In brief
Inflammatory bowel disease (IBD) are lifelong chronic diseases affecting the gastrointestinal tract. The precise etiology and the different actors participating to the pathophysiological process leading to the disease development are still not well understood. A complex interaction between genetics, gut microbiota and environmental factors is thought to trigger the inappropriate mucosal immune response observed in IBD patients. We hypothesize that DON might be an environmental risk factor for IBD.The focus on the human relevance of the gut effects of DON by studying its exposure, metabolism and adverse effects in health and disease focusing on IBD patients
Key facts
- Study ID
- NCT04960826
- Run by
- University Hospital, Lille
- People needed
- 100
- Starts
- 2021-09-27
- Expected to finish
- 2026-07-01
- Last updated by the study team
- 2025-12-26
Who can join
Age: 25 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Group 1: patients with ileocolic Crohn's disease requiring surgery
- Group 2: Patients requiring ileal and / or colonic surgery for a reason other than Crohn's disease or ulcerative colitis (for example, cancer, polyp or diverticulum).
You may not qualify if…
- Vegetarian or vegan patients, celiac disease, gluten sensitivity, eating disorders, people with a particular diet or eating behavior or suffering from obesity or anorexia
- Surgical history: patient having undergone intestinal resection
- Current treatments: patient receiving antibiotic or probiotic treatment within 6 weeks prior to inclusion / patient having taken topical treatment (suppositories or enema of 5ASA or corticosteroids) within 6 weeks prior to inclusion
Where it is running
- Lille University Hospital — Lille, France (enrolling)
Full record on ClinicalTrials.gov
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