Exercise for Memory Rehabilitation in Epilepsy

Completed · Not applicable

Conditions studied: Epilepsy, Generalized, Memory Impairment

In brief

The purpose of this study is to determine how effective a 6-week exercise program is for improving memory compared to a no-intervention control group, investigate the brain changes that may be responsible for memory improvements, and determine if the memory benefits and brain changes are retained 6 weeks after completing the exercise intervention in people with Idiopathic generalized epilepsy (IGE).

Key facts

Study ID

NCT04959019

Run by

University of Alabama at Birmingham

People needed

71

Starts

2021-07-21

Expected to finish

2026-02-18

Last updated by the study team

2026-03-11

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• males and females
• ages 18-65 years old
• speaks English fluently
• able to provide written informed consent
• have no contraindications to 3-Telsa MRI
• clinician-confirmed diagnosis of IGE (IGE includes epilepsy syndromes such as juvenile myoclonic epilepsy, juvenile absence epilepsy, childhood absence epilepsy, and generalized tonic-clonic seizures alone)
• relatively healthy with no comorbid medical conditions besides epilepsy
• normal pre-enrollment structural clinical MRI of the brain (if available)
• having less than the American Heart Association recommendation of physical activity in adults (at least 30 min moderate-intensity aerobic activity at least 5 days/week (150 min total), or at least 25 min vigorous aerobic activity at least 3 days/week (75 min total) and moderate-/high-intensity muscle strengthening activity at least 2 days/week)

You may not qualify if…

• underlying degenerative or metabolic disorders
• abnormal general or neurological examination
• abnormal brain MRI
• recent suicidal ideation in the last 3 months determined based on previous medical history
• pregnant or positive pregnancy test result on the day of the research session
• contraindication to an MRI scan at 3-Telsa
• mental handicap (FSIQ<80 if tested) or history of special education
• concurrent participation in a different intervention study
• diseased or enlarged heart or blood vessels determined based on previous medical history
• high blood pressure that is not controlled by medications
• meeting the American Heart Association recommendation of physical activity in adults
• abnormal physical examination in which study physician determines subject should not participate in the exercise intervention

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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