A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Pediatric Participants With Atypical Hemolytic Uremic Syndrome (aHUS)

Running, not enrolling · Phase 3

Conditions studied: Atypical Hemolytic Uremic Syndrome

In brief

This study aims to evaluate the efficacy and safety of crovalimab in pediatric participants with aHUS.

Key facts

Study ID: NCT04958265
Run by: Hoffmann-La Roche
People needed: 41
Starts: 2021-11-17
Expected to finish: 2029-05-19
Last updated by the study team: 2026-03-27

Who can join

Age: 0 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Body weight >= 5 kg at screening.
Vaccination against Neisseria meningitis serotypes A, C, W, and Y; vaccination against serotype B, according to national vaccination recommendations.
Vaccination against Haemophilus influenzae type B and Streptococcus pneumoniae, according to national vaccination recommendations.
For patients continuing to receive other therapies concomitantly with crovalimab (e.g., immunosuppressants, corticosteroids, mammalian target of rapamycin inhibitor (mTORi), or calcineurin inhibitors): stable dose for >=28 days prior to screening and up to the first crovalimab administration.
For female participants of childbearing potential: an agreement to remain abstinent or use contraception.
Participants with a prior kidney transplant are eligible if they have a known history of complement-mediated aHUS prior to the kidney transplant.
Onset of initial TMA presentation within 28 days prior to the first dose of crovalimab (for Naive Cohort only).
Documented treatment with either eculizumab or ravulizumab (for Switch Cohort only).
Clinical evidence of response to a C5 inhibitor (for Switch Cohort only).
Poorly controlled TMA following treatment with another C5 inhibitor (for C5 SNP participants in the Pretreated Cohort only).
Known C5 polymorphism (for C5 SNP participants in the Pretreated Cohort only).

You may not qualify if…

TMA associated with non-aHUS related renal disease.
Positive direct Coombs test.
Chronic dialysis within 90 days prior to first crovalimab administration , and /or end stage renal disease
Identified drug exposure-related TMA.
Presence or history of a condition that could trigger TMA, such as malignancy, bone marrow or organ transplant (other than kidney transplant) or autoimmune disease.
History of a kidney disease, other than aHUS.
History of Neisseria meningitidis infection within 6 months of study enrollment.
Known or suspected immune deficiency (e.g., history of frequent recurrent infections).
Positive HIV test.
Active systemic bacterial, viral, or fungal infection within 14 days before first crovalimab administration.
Presence of fever (>= 38°C) before the first crovalimab administration (If fevers are solely due to the underlying aHUS pathology, and there is no evidence or suspicion of a systemic infection, participants may enroll).
Multi-system organ dysfunction or failure.
Recent intravenous immunoglobulin (IVIg) treatment.
Pregnant or breastfeeding or intending to become pregnant.
Participation in another interventional treatment study with an investigational agent or use of any experimental therapy within 28 days of screening or within five half lives of that investigational product, whichever is greater.
Recent use of tranexamic acid.
Current or previous treatment with a complement inhibitor (for Naive Cohort only).
First initiation of plasma exchange/plasma infusions (PE/PI) should not be more than 28 days prior to first crovalimab administration (for Naive Cohort only).
Last PE/PI completed less than 2 hours prior to first crovalimab administration (for Naive Cohort only).
Receiving PE/PI within 8 weeks of the first crovalimab administration (Switch Cohort only).
Normalization of serum creatinine values at baseline (<97.5th percentile for age), (for Naive Cohort only).
Positive for active Hepatitis B and/or C infections (HBV/HCV) (for Switch Cohort and switching C5 SNP Pretreated Cohort participants who recently received C5 inhibitor treatment).
Cryoglobulinemia at screening (for Switch Cohort and C5 SNP Cohort participants who recently received C5 inhibitor treatment).
Diagnosis of a condition leading to non-aHUS TMA: Thrombotic Thrombocytopenic Purpura (TTP), Shiga Toxin producing Escherichia Coli (STEC)-TMA, Pneumococcal HUS, TMA secondary to cobalamin C defect (as demonstrated by either increased total blood homocysteine levels or MMACHC gene mutation) and TMA related to Diacylglycerol kinase ε (DGKE) nephropathy.

Where it is running

Children's Hospital Colorado — Aurora, Colorado, United States
University of Nebraska — Omaha, Nebraska, United States
Hackensack University Medical Center — Hackensack, New Jersey, United States
UZ Gent — Ghent, Belgium
UZ Leuven Gasthuisberg — Leuven, Belgium
Inst. Da Criança- Faculdade de Medicina Usp — São Paulo, São Paulo, Brazil
CHU Sainte-Justine — Montreal, Quebec, Canada
Peking University First Hospital — Beijing, China
Beijing Children's Hospital, Capital Medical University — Beijing, China
The children's hospital , Zhejiang university school of medicine — Hangzhou, China
Hôpital Arnaud de Villeneuve — Montpellier, France
Gh Necker Enfants Malades — Paris, France
Institute of Kidney Diseases and Research Centre — Ahmedabad, Gujarat, India
Medanta-The Medicity — Gurgaon, Haryana, India
All India Institute Of Medical Sciences (AIIMS) — New Delhi, National Capital Territory of Delhi, India
Aichi Children?s Health and Medical Center — Aichi, Japan
Chiba Children's Hospital — Chibashi, Chibaken, Japan
Hospital de Especialidades Puerta de Hierro S.A de C.V. — Zapopan, Mexico
Uniwersyteckie Centrum Kliniczne — Gdansk, Poland
Instytut ?Centrum Zdrowia Matki Polki — Lodz, Poland

Full record on ClinicalTrials.gov

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