A Study to Test BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) and BI 765179 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Cancer

Running, not enrolling · Phase 1

Conditions studied: Neoplasms

In brief

This study is open to adults with advanced cancer (solid tumors) and people with advanced head and neck cancer. The study has 2 parts. The purpose of Part 1 of this study is to find the highest dose of a medicine called BI 765179 that people with solid tumors can tolerate when taken alone or together with a medicine called ezabenlimab. The goal of Part 2 is to find out whether BI 765179 in combination with a medicine called pembrolizumab helps people with advanced head and neck cancer. In Part 1, each participant is put into 1 of 2 groups. Participants get BI 765179 alone or in combination with ezabenlimab as infusion into a vein every 3 weeks. In Part 2, participants are also divided into 2 groups. 1 group gets a low dose of BI 765179 in combination with pembrolizumab and the other group gets a high dose of BI 765179 in combination with pembrolizumab. Participants receive the study treatment as infusions into a vein. BI 765179, ezabenlimab, and pembrolizumab are antibodies that may help the immune system fight cancer. In this study, BI 765179 is given to people for the first time. Participants can stay in the study up to 2 years if they benefit from treatment and can tolerate it. The doctors regularly check the participants' health and note any health problems that could have been caused by the study treatment.

Key facts

Study ID

NCT04958239

Run by

Boehringer Ingelheim

People needed

151

Starts

2021-10-18

Expected to finish

2028-02-17

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All cohorts:
• Patients with locally advanced, unresectable or metastatic solid tumors who are either refractory after standard therapy for the disease or for whom standard therapy is not appropriate
• Tumor with expected high expression of Fibroblast activation protein (FAP) of the following histologies:
• Non-small cell lung carcinoma (NSCLC)
• Gastric cancer
• Esophageal adenocarcinoma or squamous cell carcinoma
• Urothelial bladder carcinoma
• Head and neck squamous cell carcinoma
• Cutaneous malignant melanoma
• Cutaneous squamous cell carcinoma
• Hepatocellular carcinoma
• Pancreatic adenocarcinoma
• Colorectal cancer
• Malignant pleural mesothelioma
• Cervical squamous cell cancer
• Ovarian carcinoma
• Triple-negative breast cancer
• At least 18 years of age at the time of the consent or over the legal age of consent in countries where that is greater than 18 years
• Signed and dated, written informed consent (IC) in accordance with ICH-GCP and local legislation prior to admission to the trial
• At least one measurable lesion outside of central nervous system (CNS) as defined per modified Response evaluation criteria in solid tumors (RECIST) v1.1
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
• Adequate liver, bone marrow and renal organ function
• Male or female patients. Women of childbearing potential (WOCBP) and men able to father a child must be ready and able to use highly effective methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. These methods must be used during the study and for at least 6 months after the last dose of the study medication. A list of contraception methods meeting these criteria is provided in the patient information.
• Patients with brain metastases are eligible provided they meet all of the following criteria:
• Brain metastases have adequately been treated and are considered stable by the Investigator

You may not qualify if…

• Phase 1a
• Currently enrolled in another investigational device or drug trial
• Previous or concomitant malignancies other than the one treated in this trial within the last 2 years except:
• Effectively treated non-melanoma skin cancers
• Effectively treated carcinoma in situ of the cervix
• Effectively treated ductal carcinoma in situ
• Other effectively treated malignancy that is considered cured by 'local treatment'
• Previous treatment with agents targeting CD137
• Known leptomeningeal disease or spinal cord compression due to disease
• Anticoagulant treatment that cannot be safely interrupted if medically needed (e.g., biopsy) based on the opinion of the Investigator
• Persistent toxicity from previous treatments that has not resolved to ≤ Common terminology criteria for adverse events (CTCAE) Grade 1 (except for alopecia, CTCAE Grade 2 neuropathy, asthenia/fatigue or grade 2 endocrinopathies controlled by replacement therapy)
• Patient has a diagnosis of immunodeficiency
• Patient with history of immunosuppressive medication within 14 days prior to the first dose of BI 765179. The following are exceptions to this criterion:
• Use of intranasal, inhaled, or topical corticosteroids, local steroid injections (e.g., intra-articular injections)
• Systemic corticosteroids at physiologic doses ≤10 mg/day (prednisone or equivalent)
• Physiological replacement dose of corticosteroids Further exclusion criteria apply.
• Phase Ib
• Disease suitable for local therapy administered with curative intent
• Participants must not have a primary tumor site of nasopharynx or sino-nasal cancer or salivary gland cancers (any histology)
• Currently enrolled in another investigational device or drug trial
• Life expectancy of <3 months and/or has rapidly progressing disease
• Diagnosed and/or treated additional malignancy within 2 years prior to randomization with the exception of curatively treated basal cell carcinoma of the skin, squamous cell carcinoma of the skin, and/or curatively resected in situ cervical and/or in situ breast cancers Further exclusion criteria apply

Where it is running

• University of Arizona — Tucson, Arizona, United States
• Beverly Hills Cancer Center — Beverly Hills, California, United States
• The University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
• Avera Cancer Institute — Sioux Falls, South Dakota, United States
• NEXT Oncology-San Antonio-65273 — San Antonio, Texas, United States
• Border Cancer Hospital — Albury, New South Wales, Australia
• Kinghorn Cancer Centre — Darlinghurst, New South Wales, Australia
• Townsville Hospital — Douglas, Queensland, Australia
• Austin Hospital — Heidelberg, Victoria, Australia
• Cliniques Universitaires Saint-Luc — Brussels, Belgium
• Universitair Ziekenhuis Antwerpen — Edegem, Belgium
• AZ Groeninge — Kortrijk, Belgium
• ICESP - Instituto do Cancer do Estado de Sao Paulo — São Paulo, Brazil
• Hospital Sírio Libanês-São Paulo-68088 — São Paulo, Brazil
• Beneficência Portuguesa - Real e Benemérita Associação Portuguesa de Beneficência — São Paulo, Brazil
• The First Affiliated Hospital Of Bengbu Medical College — Bengbu, China
• Hunan Province Tumor Hospital — Changsha, China
• Fujian Cancer Hospital — Fuzhou, China
• Affiliated Cancer Hospital and Institute of Guangzhou Medical University — Guangzhou, China
• Union Hospital Tongji Medical College Huazhong University of Science and Technology — Wuhan, China
• Masaryk Memorial Cancer Institute — Brno, Czechia
• HOP Saint-André — Bordeaux, France
• CTR Georges-François Leclerc — Dijon, France
• INS Cancérologie Ouest Saint-Herblain — Saint-Herblain, France
• Universitätsklinikum Freiburg — Freiburg im Breisgau, Germany

Full record on ClinicalTrials.gov

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