Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance Test

Completed · Phase 1 · Has a placebo group

Conditions studied: Metabolic Diseases

In brief

The goal of this study is to understand how exogenous kisspeptin affects metabolism by evaluating responses to an oral glucose tolerance test

Key facts

Study ID

NCT04958109

Run by

Massachusetts General Hospital

People needed

16

Starts

2021-10-28

Expected to finish

2022-10-31

Last updated by the study team

2026-03-06

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• History:
• over the age of 18,
• normal pubertal development
• stable weight for previous three months,
• normal body mass index (BMI between 18.5-25)
• regular menstrual cycles
• Physical examination:
• systolic BP < 140 mm Hg, diastolic < 90 mm Hg
• Laboratory studies: (per Massachusetts General Hospital reference ranges)
• normal hemoglobin
• hemoglobin A1C < 6.5%
• blood urea nitrogen, creatinine not elevated
• aspartate aminotransferase, alanine aminotransferase < 3x upper limit of normal

You may not qualify if…

• active illicit drug use,
• history of a medication reaction requiring emergency medical care,
• difficulty with blood draws.
• history of chronic disease, except well controlled thyroid disease,
• recent use of prescription medications which interfere with metabolism or reproduction (recent = within 5 half-lives of the drug). Use of levothyroxine or seasonal allergy medications is acceptable,
• history of diabetes in a first degree relative,
• use of contraceptive pills, patches or vaginal rings within last 4 weeks.
• hyperlipidemia by fasting lipid panel
• positive serum pregnancy test (for all women)

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.