A Trial of the Safety, Tolerability, and Pharmacodynamics of CVL-871 in Subjects With Dementia-Related Apathy

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Apathy in Dementia

In brief

The purpose of this study is to determine whether CVL-871 is safe and tolerable in patients with Dementia-Related Apathy and if CVL-871 shows changes in clinical measurements of apathy.

Key facts

Study ID

NCT04958031

Run by

AbbVie

People needed

41

Starts

2021-06-22

Expected to finish

2025-02-12

Last updated by the study team

2026-03-11

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets diagnostic criteria for apathy in neurocognitive disorders
• Clinically significant apathy
• Mild to Moderate Dementia (AD, FTD, VAD, or DLB)

You may not qualify if…

• Other significant psychiatric disorder(s)
• Other neurological disorders (other than AD, FTD, VAD, or DLB)

Where it is running

• Scottsdale, Arizona — Scottsdale, Arizona, United States
• Little Rock, Arkansas — Little Rock, Arkansas, United States
• San Diego, California — San Diego, California, United States
• Santa Ana, California — Santa Ana, California, United States
• New Haven, Connecticut — New Haven, Connecticut, United States
• Delray Beach, Florida — Delray Beach, Florida, United States
• Miami, Florida — Miami, Florida, United States
• Miami, Florida — Miami, Florida, United States
• Orlando, Florida — Orlando, Florida, United States
• Wellington, Florida — Wellington, Florida, United States
• Decatur, Georgia — Decatur, Georgia, United States
• Plymouth, Massachusetts — Plymouth, Massachusetts, United States
• Staten Island, New York — Staten Island, New York, United States
• Columbus, Ohio — Columbus, Ohio, United States
• Abington, Pennsylvania — Abington, Pennsylvania, United States
• Charleston, South Carolina — Charleston, South Carolina, United States
• Fairfax, Virginia — Fairfax, Virginia, United States
• Calgary, Alberta — Calgary, Alberta, Canada
• Victoria, British Columbia — Victoria, British Columbia, Canada
• Toronto, Ontario — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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