Effect of Citrate Dialysate on Vascular Calcification

Completed · Not applicable

Conditions studied: Vascular Calcification

In brief

The goal of this study is to determine whether hemodialysis with citrate slows the progression of vascular calcification. Participants will be dialyzed with one of two standard dialysis solutions, one with and one without citrate, for 12 months and then switched to the other solution for 12 months. Vascular calcification will be measured on mammograms that will be performed at 6-month intervals and additional blood samples will be obtained at 6-month intervals.

Key facts

Study ID

NCT04956120

Run by

Emory University

People needed

54

Starts

2021-05-27

Expected to finish

2025-03-18

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• hemodialysis patients with BAC on mammograms

You may not qualify if…

• current warfarin use
• severe hyperparathyroidism (likely to undergo parathyroidectomy in the next 2 years)
• difficulty controlling serum calcium (likely to require changes in dialysate calcium concentration in the next 2 years)
• life expectancy < 2 years
• prisoners
• inability to give consent

Where it is running

• Emory Dialysis at Northside — Atlanta, Georgia, United States
• Emory Dialysis at Greenbriar — Atlanta, Georgia, United States
• Emory Dialysis at North Decatur — Decatur, Georgia, United States
• Emory Dialysis at Candler — Decatur, Georgia, United States

Full record on ClinicalTrials.gov

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