Structured Program of Exercise for Recipients of Kidney Transplantation

Recruiting now · Not applicable

Conditions studied: Kidney Transplant; Complications, Dialysis; Complications, Physical Disability, Frailty Syndrome

In brief

Older patients with end- stage kidney disease (ESKD) are at very high risk for functional impairment. Kidney transplantation (KT) has the potential to ameliorate the detrimental effects of ESKD on physical activity and functional status. However, KT alone may not meet the full extent of this potential, particularly for older or more impaired adults. In fact, activity declines immediately post-KT and fails to return to expected levels even 5 years post-KT. Older patients waitlisted for KT (most of whom are on dialysis) are therefore reliant on their pre-KT levels of exercise, which are also predictive of post-KT mortality. "Prehabilitation" has been used in other surgical populations to minimize functional loss, and a structured exercise program may be beneficial in the pre- KT setting. However, few waitlisted patients are able to participate in typical exercise interventions due to barriers such as severe fatigue. Older patients have additional barriers such as further mobility impairment and requiring substantial caregiver support. Therefore for older living donor kidney transplant candidates, it is necessary to address issues such as specifics of coaching, timing, and importantly, incorporate caregiver participation. The overall objective of this proposal is to adapt a previously developed 8- week, home- based, structured exercise program among older (≥50 years) dialysis patients awaiting living donor KT, with a focus on caregiver involvement. The investigators will trial the exercise program as compared to usual care. The investigators will then pilot the refined intervention in a total of 72 patient-caregiver dyads, 48 of whom will undergo the proposed intervention (24 with caregiver participation, 24 without). The primary outcomes for the pilot will be change in physical performance and activity from baseline to after the intervention, along with measurements of exploratory quality of life outcomes. In addition, the investigators will measure these same outcomes at 3- months post KT to evaluate for a durable effect of the intervention. An additional post-transplantation outcome of interest will be number of days hospitalized within 3 months of transplantation.

Key facts

Study ID

NCT04954690

Run by

University of California, San Francisco

People needed

136

Starts

2022-11-22

Expected to finish

2029-07-01

Last updated by the study team

2023-10-16

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• On hemodialysis or peritoneal dialysis
• Age ≥ 50 years
• SPPB score ≤ 10
• Telephone access
• Internet access
• Having a living donor kidney

You may not qualify if…

• Already in an exercise program
• Non-English speakers

Where it is running

• Connie Frank Center for Kidney Transplantation at the University of California, San Francisco Medical Center — San Francisco, California, United States (enrolling)

Full record on ClinicalTrials.gov

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