Study of NIS793 and Other Novel Investigational Combinations With SOC Anti-cancer Therapy for the 2L Treatment of mCRC

Stopped early · Phase 2

Conditions studied: Metastatic Colorectal Cancer

In brief

The purpose of this study is to evaluate the preliminary efficacy and safety of NIS793 and other novel investigational combinations with standard of care (SOC) anti-cancer therapy vs SOC anti-cancer therapy for the second line treatment of mCRC. This study aims to explore whether different mechanisms of action may reverse resistance and improve responsiveness to the currently considered SOC anti-cancer therapy in the second line metastatic colorectal cancer (mCRC) setting.

Key facts

Study ID

NCT04952753

Run by

Novartis Pharmaceuticals

People needed

204

Starts

2021-11-15

Expected to finish

2025-01-20

Last updated by the study team

2025-03-26

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of Michigan Medical — Ann Arbor, Michigan, United States
• WA Uni School Of Med — St Louis, Missouri, United States
• Astera Cancer Center — East Brunswick, New Jersey, United States
• Sarah Cannon Research Institute — Nashville, Tennessee, United States
• Uni Of TX MD Anderson Cancer Cntr — Houston, Texas, United States
• Mays Cancer Center — San Antonio, Texas, United States
• Novartis Investigative Site — Adelaide, South Australia, Australia
• Novartis Investigative Site — Bendigo, Victoria, Australia
• Novartis Investigative Site — Perth, Western Australia, Australia
• Novartis Investigative Site — Brussels, Belgium
• Novartis Investigative Site — Brussels, Belgium
• Novartis Investigative Site — Leuven, Belgium
• Novartis Investigative Site — Brampton, Ontario, Canada
• Novartis Investigative Site — Cambridge, Ontario, Canada
• Novartis Investigative Site — Montreal, Quebec, Canada
• Novartis Investigative Site — Montreal, Quebec, Canada
• Novartis Investigative Site — Brno, Czech Republic, Czechia
• Novartis Investigative Site — Hradec Králové, CZE, Czechia
• Novartis Investigative Site — Prague, Czechia
• Novartis Investigative Site — Avignon, France
• Novartis Investigative Site — Créteil, France
• Novartis Investigative Site — Nantes, France
• Novartis Investigative Site — Frankfurt am Main, Hesse, Germany
• Novartis Investigative Site — Berlin, Germany
• The Angeles Clinic and Research Institute — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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