Geniculate Artery Embolization for Knee Osteoarthritis
Completed · Not applicable
Conditions studied: Knee Osteoarthritis
In brief
The purpose of this study is to perform a prospective case series to determine efficacy of transcatheter arterial embolization in treating knee osteoarthritis related pain, improving functionality, and reducing opiate usage in patients with mild to moderate knee osteoarthritis who have failed conservative management. The Gel-Bead embolization particles will be used to perform geniculate artery embolization (GAE) for the purposes of treatment of osteoarthritis-related knee pain.
Key facts
- Study ID
- NCT04951479
- Run by
- Anish Ghodadra
- People needed
- 11
- Starts
- 2021-11-03
- Expected to finish
- 2023-10-26
- Last updated by the study team
- 2025-04-09
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients between ages 18 and 75 with moderate/severe knee pain secondary to primary osteoarthritis. Moderate/severe pain will be defined as pain 30 mm to 100 mm on the Visual Analog Pain Scale (where 0 denotes 'no pain' and 100 mm denotes worst pain imaginable')
- Grade 1, 2, or 3 osteoarthritis on the Kellgren-Lawrence grading scale on knee x-ray in the last 6 months
- Pain must be refractory to 3 months of medical management (which may include a combination of oral analgesics, intraarticular steroids, viscosupplementation, opioid therapy, etc)
- Patients willing and able to consent to the study
You may not qualify if…
- Kidney dysfunction defined as an estimated GFR < 60 mL/min
- Acute knee injury
- Current local infection
- Prior ipsilateral knee replacement surgery
- Infectious or inflammatory arthritis
- History of contrast allergy resulting in anaphylaxis
- INR (International Normalization Ratio) > 1.6
- Platelets < 50,000
- Significant atherosclerosis that would limit angiography
- Active malignancy
- Active pregnancy
- Appropriate candidate for knee replacement surgery determined by clinical and physical examination
- Recent within 3 months, or active cigarette user
Where it is running
- UPMC Shadyside — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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