The Effect of Local Tranexamic Acid on Post-operative Edema and Ecchymosis in Eyelid Surgery

Status unconfirmed · Phase 4

Conditions studied: Edema, Ecchymosis; Eyelid

In brief

Tranexamic acid (TXA) is a synthetic inhibitor of plasminogen lysine receptor that has used to reduce intra-operative bleeding in a number of clinical scenarios. Anecdotally, TXA has used by plastic surgeons to reduce post-operative bruising. To date, there is limited data to valid the benefits and to evaluate the side effects of TXA. The objective of this study is to evaluate the effect of local TXA on edema and ecchymosis in eyelid surgery.

Key facts

Study ID

NCT04951128

Run by

Consultants in Ophthalmic and Facial Plastics Surgery

People needed

50

Starts

2021-08-01

Expected to finish

2022-07-01

Last updated by the study team

2021-07-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Older than 18 years old
• Undergo bilateral upper/lower eyelid blepharoplasty, bilateral upper eyelid ptosis repair, or a combination of the above procedures
• Additional concurrent forehead/brow or upper/lower eyelids surgeries may be included if bilateral

You may not qualify if…

• Prior eyelid surgery
• Anticoagulant or antiplatelet use, including aspirin, within 7 days prior to surgery
• Patient who is currently pregnant or breast feeding
• Patient with color vision deficiency
• TXA allergy
• History of bleeding disorder
• History of clotting disorder
• History of seizure
• Have active nausea/vomiting/gastrointestinal symptoms
• Have active intracranial bleeding
• Have active periocular ecchymosis or edema prior to surgery

Where it is running

• Consultants in Ophthalmic and Facial Plastic Surgery — Southfield, Michigan, United States
• Montefiore Medical Center — The Bronx, New York, United States
• Houston Methodist — Houston, Texas, United States
• University of Texas - Health Science Center at Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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