Falls: A Marker of Preclinical AD

Completed

Conditions studied: Fall, Alzheimer Disease

In brief

This longitudinal cohort study investigates cognitively normal participants with and without preclinical Alzheimer disease (AD) in order to examine: (1) the relationship between falls and functional mobility in preclinical stages of AD; and (2) a hypothesized model of central and peripheral mechanism(s) underlying falls and functional mobility in preclinical stages of AD.

Key facts

Study ID

NCT04949529

Run by

Washington University School of Medicine

People needed

355

Starts

2019-03-07

Expected to finish

2025-04-30

Last updated by the study team

2026-07-22

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 65 years of age or older
• cognitively normal (Clinical Dementia Rating [CDR] score of 0)
• A pilot sub-study collecting stool will also enroll a few individuals with CDR>0 for comparison.
• have biomarkers (CSF), and/or neuroimaging (positron emission tomography [PET] and/or magnetic resonance imaging [MRI]) within 2 years of enrolling in this study.

You may not qualify if…

• History of Parkinson's disease.

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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