Poor Grade Aneurysmal Subarachnoid Hemorrhage Study Group

Recruiting now

Conditions studied: Subarachnoid Hemorrhage, Aneurysmal, Poor Grade Subarachnoid Hemorrhage

In brief

Multicentric registry study in order to define outcome, predictors, treatment effects and their modifiers in poor grade aneurysmal subarachnoid haemorrhage patients. The search for outcome predictors is going to be subdivided into three main research areas: 1. outcome predictors in the emergency department (so called "early brain injury phase"). 2. outcome predictors in the neurocritical care unit (so called "delayed brain injury phase"). 3. Treatment strategies. Two other areas of research are identified: delayed cerebral ischemia (incidence, treatment, predictors, impact on outcome) and long term follow-up (recent evidences suggest that there may be a non-negligible proportion of poor grade subarachnoid hemorrhage patients who may benefit from substantial improvement at long-term (after 6-12 months of follow-up).

Key facts

Study ID

NCT04945603

Run by

IRCCS San Raffaele

People needed

800

Starts

2021-05-25

Expected to finish

2028-12-31

Last updated by the study team

2023-11-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients admitted to the emergency department because of aneurysmal subarachnoid hemorrhage of poor grade (IV-V) according to the WFNS classification.

You may not qualify if…

• Patients younger than 18 years old.
• Pregnant or breast-feeding patients.
• Aneurysmal subarachnoid hemorrhage due to trauma or vascular malformations other than cerebral aneurysms.

Where it is running

• Azienda Ospedaliera Universitaria Integrata — Verona, Italy (enrolling)
• IRCCS Bellaria — Bologna, Italy (enrolling)
• Azienda Ospedaliera Spedali Civili — Brescia, Italy (enrolling)
• Ospedale Vito Fazzi — Lecce, Italy (enrolling)
• IRCCS San Raffaele — Milan, Italy (enrolling)
• Ospedale Maggiore della Città di Novara — Novara, Italy (enrolling)
• Azienda Ospedaliero-Universitaria di Parma — Parma, Italy (enrolling)
• Ospedale Santissima Annunziata — Taranto, Italy (enrolling)
• ASST Ospedale Papa Giovanni XXIII — Bergamo, Italy
• Policlinico Universitario Agostino Gemelli — Roma, Italy

Full record on ClinicalTrials.gov

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