Cognitive Process-based Real-time fMRI Neurofeedback in MDD and Rumination

Completed · Not applicable · Has a placebo group

Conditions studied: Depression, Anxiety

In brief

The purpose of this study is to assess the feasibility and efficacy of real-time fMRI neurofeedback for rumination.

Key facts

Study ID: NCT04941066
Run by: Laureate Institute for Brain Research, Inc.
People needed: 44
Starts: 2021-03-01
Expected to finish: 2022-03-31
Last updated by the study team: 2023-01-18

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Good general health
DSM-5 diagnosis of major depressive disorder (MDD)

You may not qualify if…

General Exclusion Criteria:
Pregnancy
Medical Conditions:
Moderate to severe traumatic brain injury (>30 min. loss of consciousness or >24 hours posttraumatic amnesia) or other neurocognitive disorder with evidence of neurological deficits.
Presence of co-morbid medical conditions not limited to but including cardiovascular (e.g., history of acute coronary event, stroke) and neurological diseases (e.g., Parkinson's disease), as well as pain disorders.
Presence of an uncontrolled medical condition that is deemed by the investigators to interfere with the proposed study procedures, or to put the study participant at undue risk.
Psychiatric Disorders:
Current severe suicidal ideation or attempt within the past 12 months.
Psychosis
Bipolar disorder
Substance abuse or dependence within the previous 6 months
Contraindications for MRI:
Bodily implants of unsafe paramagnetic materials such as pace-makers and aneurysm clips.
Claustrophobia that is severe enough to preclude MRI scanning.
Medications:
Evidence of recreational drug use from a urine test.

Where it is running

Laureate Institute for Brain Research — Tulsa, Oklahoma, United States

Full record on ClinicalTrials.gov

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