Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

Recruiting now · Not applicable

Conditions studied: Psychosis, Schizophrenia

In brief

The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.

Key facts

Study ID

NCT04940663

Run by

Massachusetts General Hospital

People needed

120

Starts

2022-07-13

Expected to finish

2027-01-01

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-55 years old
• Experienced a psychotic disorder or mood disorder

You may not qualify if…

• Any neurological disorder or current substance use disorder (during the past 6 months)
• Not proficient in English
• A recent change in medication, or an acute symptom presentation
• Standard exclusion criteria for participation in an MRI scan (e.g., presence of metal in the body, claustrophobia, a history of head trauma).

Where it is running

• Massachusetts General Hospital — Charlestown, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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