Eye Movement Testing in Patients With Obesity and the Impact of Weight Loss Surgery
Stopped early
Conditions studied: Bariatric Surgery Candidate, Obesity, Morbid
In brief
Obesity is a condition of chronic low-grade inflammation, thought to be secondary to adipose tissue secretion of cytokines including interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF- α) which effect multiple pathways and lead to an increase in C-reactive protein (CRP), a sensitive marker of systemic inflammation. Chronic inflammation is thought to be a major risk factor for the development of metabolic syndrome, diabetes, cardiovascular disease and cancer. Inflammatory cytokines have also been shown to directly and indirectly interact with the central nervous system influencing behavior and neural activity. Obesity is an independent risk factor for reduced cognitive function including poor attention, executive function and memory. Demonstrating improvement in dynamic visual processing following bariatric surgery could expand our understanding of the impact of obesity on central nervous system (CNS) function.
Key facts
- Study ID
- NCT04940429
- Run by
- Stanford University
- People needed
- 19
- Starts
- 2018-11-27
- Expected to finish
- 2021-06-17
- Last updated by the study team
- 2021-06-25
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients who are overweight or obese (Body Mass Index over 25 and 30, respectively)
You may not qualify if…
- Individuals <18 years
- Patients with history of cognitive brain disease including traumatic brain injury, dementia, Parkinson's disease
- Individuals with uncontrolled neuropsychiatric illnesses or overt hepatic encephalopathy
- Ongoing alcohol or illicit substance use
- patients with cirrhosis
Where it is running
- Stanford University School of Medicine — Redwood City, California, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.