Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring
Recruiting now · Phase 4 · Has a placebo group
Conditions studied: Intraoperative Neurophysiological Monitoring, Magnesium Sulfate
In brief
Magnesium Sulfate(MgSo4) is increasingly being used as part of the multimodal pain regimen in the perioperative period. The intraoperative neurophysiological monitoring (IONM) is utilized in complex spine and cranial surgeries to assess the functional integrity of the neural pathways. The effect of Magnesium sulfate on IONM has not been studied. This is a prospective, double blind, randomized placebo controlled trial to study the effect of Magnesium sulfate bolus on the amplitude and latency of somatosensory(SSEPs) and motor evoked potentials(MEPs) in patients undergoing surgery requiring IONM.
Key facts
- Study ID
- NCT04938765
- Run by
- Loma Linda University
- People needed
- 50
- Starts
- 2022-03-18
- Expected to finish
- 2027-03-01
- Last updated by the study team
- 2026-04-24
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Magnesium use within the last 2 days, either intravenous or oral supplements.
- Patients with known electrolyte imbalances (Sodium <135 or >145 mmol/L OR Potassium < 3.5 or > 5.0 mmol/L, Magnesium >1.2 mmol/L.
- Severe cardiac or cardiac conduction disorders.
- Severe pulmonary disease.
- Patients with significant neuromuscular disorders or preexisting motor or sensory deficits other than focal upper limb neuropathy or focal cervical radiculopathy or mild cervical myelopathy.
- Severe Renal disease - serum creatinine of > 2 mg/dl.
- Pregnant or breastfeeding patients.
- Unable to obtain adequate baseline SSEPs and MEPs.
Where it is running
- Loma linda University Medical Center — Loma Linda, California, United States (enrolling)
Full record on ClinicalTrials.gov
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