Mitigating the Pro-inflammatory Phenotype of Obesity

Recruiting now · Phase 1 · Has a placebo group

Conditions studied: Blood Pressure, Diabetes, Obesity, Insulin Resistance, Diuretics Drug Reactions, Sympathetic Nerve Activity

In brief

The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α, IL-6). Our study is a prospective study using a randomized, double-blinded design to test 4 weeks of SNA blockade (oral clonidine) compared with a BP-lowering control condition (diuretic, hydrochlorothiazide) or a placebo.

Key facts

Study ID

NCT04934228

Run by

University of Kansas Medical Center

People needed

60

Starts

2021-07-01

Expected to finish

2027-08-01

Last updated by the study team

2025-06-05

Who can join

Age: 18 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or Female, age 18-79
• Obese: BMI > 30 m/kg2
• Hypertensive: blood pressure >130/80
• Elevated insulin resistance (HOMA-IR > 2.5)
• Waist circ: >102 cm (men) and >88 cm (women)
• Fasting glucose < 126 mg/dL
• Fasting triglycerides < 250 mg/dL
• HbA1c < 6.5%
• Willing to visit research lab (Fairway CTSU)
• Willing to undergo a blood draw
• Able to provide written informed consent

You may not qualify if…

• Current use of clonidine or beta-blockers
• Current smoker or History of smoking in the past 3 months.
• Hyperlipidemia: Fasting triglycerides > 250 mg/dL
• Currently taking hypertension medication
• History of heart disease (e.g., myocardial infarction, stent, byass, heart attack, stroke, heart failure, valvular heart disease, cardiomyopathy)
• History of neurological disorders
• History of transplant
• Actively participating in other studies, except for a registry study.

Where it is running

• University of Kansas Medical Center — Kansas City, Kansas, United States (enrolling)

Full record on ClinicalTrials.gov

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