Bilateral Lateral OFC rTMS in Obsessive Compulsive Disorder

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Obsessive-Compulsive Disorder

In brief

According to the literature the lateral part of the Orbito Frontal Cortex (lOFC) is a relevant bilateral target for repetitive Trans-cranial Magnetic Stimulation (rTMS) in Obsessive Compulsive Disorder (OCD). Both hemispheres are concerned in terms of target.

Key facts

Study ID: NCT04934007
Run by: Centre Hospitalier Henri Laborit
People needed: 136
Starts: 2021-09-06
Expected to finish: 2027-09-01
Last updated by the study team: 2026-01-13

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age: Participants will be both males and females, 18-65 years of age included.
diagnosis of OCD
all the patients must have failed to respond to at least two different pharmacological treatment used for at least 6 weeks
Affiliation to a social security system (recipient or assignee),
Signed written inform consent form

You may not qualify if…

The exclusion criteria are a diagnosis of another psychiatric disorder (except for anxious disorders), a diagnosis of a significant active medical illness, pregnancy or other neurological illness
In accordance with the safety criteria for rTMS, patients with a history of seizure or bearing pacemakers, mobile metal implants, implanted medical pumps, or metal clips placed inside the skull will also be excluded
The patients won't be allowed to change their medication during the trial. The treatment must be stable at least 3 week before day 0.
Female subject who is pregnant, or of child-bearing age, sexually active and not using reliable contraception or who is nursing,
Patient under curators
Patient hospitalized under duress
Patient unable to give his or hers informed consent

Where it is running

Sorbonne University, Pitié-Salpêtrière Hospital — Paris, France (enrolling)
Centre Hospitalier Henri Laborit — Poitiers, France (enrolling)

Full record on ClinicalTrials.gov

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