Regular vs. Clear Liquid Diet for Mild to Moderate Acute Pancreatitis

Status unconfirmed · Not applicable

Conditions studied: Pancreatitis, Diet, Food, and Nutrition, Diet, Pancreatic Disease, Enteral Nutrition

In brief

Acute pancreatitis is among the most common gastroenterology diagnosis in the United States, and represents a large economic burden to the United States health system. While recent guidelines agree early feeding shortens length of stay, these guidelines fail to provide recommendations on optimal diet to start leaving diet type to clinician discretion. Therefore, the aim is to assess the comparative efficacy of full calorie regular diet (RD) versus clear liquid diet (CLD) on length of hospital stay (LOHS) for mild to moderate acute pancreatitis (AP). The study population will target mild to moderate acute pancreatitis patients who can tolerate eating in a single institution. The primary end point will focus on LOHS, and secondary end points will include Pancreatic Activity Scoring System, side effects and readmission.

Key facts

Study ID

NCT04932785

Run by

University of Southern California

People needed

150

Starts

2021-07-18

Expected to finish

2024-07-01

Last updated by the study team

2023-03-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• >18 years of age
• Presentation with acute pancreatitis as defined by two of three criterion per the Revised Atlanta Criteria guidelines: (a) Amylase or lipase > 3x the upper limit of normal, b) Classical abdominal pain, c) Ultrasound or computed tomography of unequivocal pancreatitis. Such radiographic findings include swelling, edema, or heterogeneity of the gland or peripancreatic fluid or stranding

You may not qualify if…

• Pregnant or breastfeeding women
• Incarcerated patients
• Patients < 18 years of age
• Patient unable or unwilling to give informed consent
• Patients transferred from another hospital
• The possibility of poor oral intake for reasons other than acute pancreatitis (e.g. intubation, failure to pass an indicated swallow study for aspiration risk, anorexia secondary to active malignancy, etc)
• Surgical intervention for infected pancreatic necrosis or pancreatic hemorrhage
• Chronic pancreatitis based on radiographic evidence
• Severe pancreatitis based on Revised Atlanta Criteria. Under Revised Atlanta Criteria, patients will be excluded if they have a composite Modified Marshall >2
• Etiologies of hypertriglyceridemia, trauma and autoimmune pancreatitis will be excluded

Where it is running

• LAC+USC Medical Center — Los Angeles, California, United States (enrolling)

Full record on ClinicalTrials.gov

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