Mechanical Bowel Prep Randomized Study

Starting soon · Not applicable

Conditions studied: Colorectal Surgery

In brief

Following colon surgery, surgical site infection (SSI) is the most common complication and leads to longer recovery time for patients and increased health care costs. Currently, there is high quality evidence to show that the combination of intravenous antibiotics (IVA), mechanical bowel preparation (MBP) and oral antibiotics (OA) is the most effective bowel preparation to reduce SSI. However, there are no studies comparing IVA+MBP+OA and IVA+OA. This is an important question because if IVA+OA works the same as IVA+MBP+OA, then MBP may be safely omitted as part of the bowel preparation to reduce SSI and patients would avoid the side effects of MBP prior to their surgery. Therefore, the objective is to perform a trial to determine if IVA+OA works the same as IVA+MBP+OA to reduce SSI following colon surgery.

Key facts

Study ID

NCT04931173

Run by

Mount Sinai Hospital, Canada

People needed

1062

Starts

2026-09-01

Expected to finish

2028-12-01

Last updated by the study team

2026-06-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• undergoing elective colon surgery for benign or malignant disease
• over the age of 18 years
• provides informed consent.

You may not qualify if…

• known anaphylaxis to neomycin or metronidazole
• pregnancy or lactation
• chronic renal failure (serum creatinine > 220 umol/L).

Full record on ClinicalTrials.gov

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