Social Interventions for Support During Treatment for Endometrial Cancer and Recurrence

Running, not enrolling · Not applicable

Conditions studied: Endometrial Cancer

In brief

The SISTER study is a randomized trial, looking at various modalities of social support for Black patients undergoing treatment for endometrial cancer. There are three study arms: group support, 1:1 peer support, and enhanced usual care. The primary outcome is treatment completion, and the secondary outcome is social isolation.

Key facts

Study ID

NCT04930159

Run by

University of Washington

People needed

252

Starts

2021-09-01

Expected to finish

2026-10-31

Last updated by the study team

2026-04-28

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Adult 18 years of age or older; and
• Self-identify as Black/African American
• Presenting with high-risk EC established by anatomic pathology as tumor stage and grade classification by the following:
• Pathology documentation from any hospital/clinic/medical center, and
• FIGO Stage 1A with Grade 2, Grade 3, or Grade 4 of any histology type or
• FIGO Stage 1A with non-endometrioid (carcinosarcoma, serous, clear cell, undifferentiated or mixed) histology
• FIGO Stage 1B, 2, 3, or 4 of any grade or histology
• Recurrent endometrial cancer of any stage or grade
• Documented provider recommendation and patient plan to initiate adjuvant therapy with chemotherapy, radiation, and/or immunotherapy.

You may not qualify if…

• Participants must not have any of the following exclusion criteria:
• Newly diagnosis of FIGO Stage IA Grade 1 endometrioid adenocarcinoma
• Previous history of other cancer diagnosis requiring chemotherapy, radiation therapy, or immunotherapy within the past 12 months;
• Incarcerated in a detention facility or in police custody (patients wearing a monitoring device can be enrolled) at baseline/screening;
• Contraindication to all non-surgical therapy available for endometrial cancer (i.e., chemotherapy, radiation, and immunotherapy contraindicated);
• Enrollment into hospice prior to randomization
• Unable to provide written informed consent in English;
• Unable to be contacted for research surveys;
• Recent hospitalization for psychiatric illness in the past 6 months

Where it is running

• University of Alabama — Birmingham, Alabama, United States
• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• University of Miami — Miami, Florida, United States
• The University of Chicago — Chicago, Illinois, United States
• Louisiana State University - New Orleans — New Orleans, Louisiana, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• MedStar Health Research Institute — Columbia, Maryland, United States
• Weill Cornell Medicine — New York, New York, United States
• University of North Carolina — Chapel Hill, North Carolina, United States
• University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
• Fred Hutch/University of Washington Cancer Consortium — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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