Hypertonic Saline for MAC
Recruiting now · Phase 4
Conditions studied: Nontuberculous Mycobacterial Lung Disease, Nontuberculous Mycobacterium Infection
In brief
The MAC-HS study is a testing whether hypertonic saline helps improve symptoms and clearance of mycobacteria in patients with M. avium complex lung infections.
Key facts
- Study ID
- NCT04921943
- Run by
- Oregon Health and Science University
- People needed
- 50
- Starts
- 2021-05-18
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2025-08-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- At least 2 positive MAC sputum cultures in the last 12 months with at least one AFB positive sputum obtained within 12 weeks prior to randomization
- Meet American Thoracic Society (ATS)/ Infectious Disease Society of America (IDSA) 2007 pulmonary clinical disease criteria[1]
- Age 18 and older
- Diagnosis of Bronchiectasis and/or bronchiectatic findings evident on chest CT report
- Ability to provide informed consent
You may not qualify if…
- Any patient who is unwilling or unable to provide consent or to comply with this protocol
- Cavitary NTM disease
- Patients who are currently taking or within the prior 6 months received any of the following: bedaquiline, or any component of ATS/IDSA multi-drug recommended therapy (macrolide, ethambutol, rifampin) for MAC treatment
- Diagnosis of HIV
- Diagnosis of Cystic fibrosis
- Active pulmonary tuberculosis, fungal, or nocardial disease requiring treatment at screening
- Current use of chronic systemic corticosteroids at doses of 15 mg/day for more than 3 months
- Prior lung or other solid organ transplant
Where it is running
- Oregon Health & Science University — Portland, Oregon, United States (enrolling)
- University Health Network — Toronto, Ontario, Canada (enrolling)
- NYU Langone Health — New York, New York, United States
Full record on ClinicalTrials.gov
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