Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy
Completed · Not applicable
Conditions studied: Chemotherapy-induced Neuropathy
In brief
The proposed randomized control trial will evaluate auricular point acupressure (APA) on chemotherapy-induced neuropathy (CIN), rigorously considering point specificity and placebo effects by integrating self-report measures, psychophysical measures (QST), endogenous biomarkers (cytokines), and neuro-imaging to investigate APA's efficacy and underlying mechanism(s).
Key facts
- Study ID
- NCT04920097
- Run by
- The University of Texas Health Science Center, Houston
- People needed
- 238
- Starts
- 2021-07-08
- Expected to finish
- 2026-03-19
- Last updated by the study team
- 2026-08-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- cancer patients ages ≥18 years
- have received a medication in one of the following categories: platinum-based, vinca alkaloids, bortezomib, eribulin, and/or taxanes
- have CIN due to receiving neurotoxic chemotherapy for cancer or have pre-existing peripheral neuropathy of another etiology that worsened after chemotherapy
- have one of the average intensity of pain, or numbness, or tingling on their extremities the previous week due to CIN ≥ 4 on a 11-point numerical scale.
You may not qualify if…
- use of an investigational agent for pain control concurrently or within the past 30 days
- use of an implantable drug delivery system, e.g. Medtronic SynchroMed®
- prior celiac plexus block or other neurolytic pain control treatment
- other identified causes of painful paresthesia existing prior to chemotherapy (e.g., radiation or malignant plexopathy, lumbar or cervical radiculopathy,)
- allergy to latex (the tapes for the APA include latex) and/or having a history of allergic reactions to the adhesive tape
- pregnant women (based on the self-reported data)
- individuals diagnosed with diabetic neuropathy
Where it is running
- Johns Hopkins University — Baltimore, Maryland, United States
- The University of Texas Health Science Center at Houston — Houston, Texas, United States
Full record on ClinicalTrials.gov
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