A Study of BI 765128 in Patients With an Eye Condition Called Diabetic Macular Ischemia Who Have Received Laser Treatment

Completed · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Diabetic Retinopathy

In brief

This study is open to adults with diabetic macular ischemia who have received laser treatment. The main purpose of this study is to find out whether people with diabetic macular ischemia can tolerate a medicine called BI 765128. In this study, BI 765128 is given to people for the first time. The study has 2 parts. Part A tests 3 doses of BI 765128. Participants get either a low, medium or high dose of BI 765128 as a single injection into the eye. If participants tolerate it well, the highest dose will be used in part B. In part B, participants are put into 2 groups randomly, which means by chance. 1 group gets BI 765128 as injection into the eye. The other group gets sham injections. A sham injection means that it is not a real injection and contains no medicine. Participants cannot tell whether they get the real injection or a sham injection. In this part, participants receive study treatment once every month for 3 months. Participants in part A are in the study for about 4 months and visit the study site about 8 times. Participants in part B are in the study for about 5 months and visit the study site about 7 times. The doctors regularly check participants' health and take note of any unwanted effects.

Key facts

Study ID

NCT04919499

Run by

Boehringer Ingelheim

People needed

46

Starts

2021-07-30

Expected to finish

2023-08-07

Last updated by the study team

2024-11-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Part A
• Panretinal photocoagulation-treated diabetic retinopathy (DR) patients with either no or inactive retinal neovascularization per investigator judgement in the study eye
• Male or female subjects of age ≥ 18 years
• Evidence of diabetic macular ischemia (DMI) per investigator´s judgement, defined as any degree of disruption of retinal vascularity in optical coherent tomography angiography (OCTA)
• Glycosylated Hemoglobin, Type A1C (HbA1c) of ≤ 12.0%
• Best-corrected visual acuity (VA) ≤75 letters (20/32) in the study eye
• Best corrected visual acuity (VA) in the non-study eye must be equal to or better than best corrected VA in the study eye. If both eyes are eligible and have identical best corrected VA the investigator may select the study eye.
• Women of childbearing potential (WOCBP) and men able to father a child must be ready and able to use two methods of contraception with at least one of them being a highly effective method of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly.
• Signed and dated written informed consent in accordance with International Council for Harmonisation-Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial
• Part B:
• Panretinal photocoagulation-treated diabetic retinopathy (DR) patients with either no or inactive retinal neovascularization per investigator judgement
• Male or female subjects of age ≥ 18 years
• Presence of significant diabetic macular ischemia (DMI): Large foveal avascular zone (FAZ) defined as those with ≥0.5mm2 area present on optical coherent tomography angiography (OCTA). If FAZ is <0.5mm2 then an enlarged peri-foveal inter-capillary space in at least 1 quadrant will be sufficient.
• Glycosylated Hemoglobin, Type A1C (HbA1c) of ≤ 12.0%
• Best-corrected visual acuity (VA) ≤85 letters (20/20) in the study eye
• If both eyes are eligible, the investigator may select either eye to be the study eye.
• Women of childbearing potential (WOCBP) and men able to father a child must be ready and able to use two methods of contraception with at least one of them being a highly effective method of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly.
• Signed and dated written informed consent in accordance with International Council for Harmonisation-Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial

You may not qualify if…

• Part A:
• Subjects receiving intravitreal (IVT) injections for active Diabetic Macular Edema (DME) (anti-vascular endothelial growth factor (VEGF), steroids) and macular laser in the previous 3 months to screening in the study eye
• Subjects receiving anti-VEGF IVT injections for active diabetic retinopathy (DR) in the previous 3 months to screening in the study eye
• Current or planned use of medications known to be toxic to the retina, lens or optic nerve (e.g. desferoxamine, chloroquine/hydrochloroquine, chlorpromazine, phenothiazines, tamoxifen, nicotinic acid, and ethambutol)
• Additional progressive eye disease in the study eye that could compromise best corrected visual acuity (VA) (best corrected visual acuity (BCVA)), uncontrolled glaucoma (intra-ocular pressure (IOP)>24), history of high myopia > 8 diopters in the study eye. Anterior segment and vitreous abnormalities in the study eye that would preclude adequate observation with spectral domain optical coherence tomography (SD-OCT) and optical coherent tomography angiography (OCTA).
• Any intraocular surgery in the study eye within 3 months prior to screening
• Glaucoma tube shunts
• Aphakia or total absence of the posterior capsule. Yttrium aluminum garnet (YAG) laser capsulotomy permitted, if completed more than 3 months prior to screening, in the study eye
• Subjects not expected to comply with the protocol requirements or not expected to complete the trial as scheduled (e.g. chronic alcohol or drug abuse or any other condition that, in the investigator´s opinion, makes the subject an unreliable trial subject) Further exclusion criteria apply
• Part B:
• Diabetic Macular Edema (DME), defined as a Central Subfield Thickness (CST) ≥ 305μm for men and ≥ 290 μm for women (Optovue Angiovue) in the study eye
• Subjects receiving intravitreal (IVT) injections for active DME (anti-vascular endothelial growth factor (VEGF), steroids) and macular laser in the previous 3 months to screening in the study eye
• Subjects receiving anti-VEGF intravitreal IVT injections for active Diabetic Retinopathy (DR) in the previous 3 months to screening in the study eye
• Heavily lasered macula in the study eye per investigator judgement
• History of vitrectomy in the study eye
• Epiretinal membrane with extended foveal contour distortion in the study eye
• Current or planned use of medications known to be toxic to the retina, lens or optic nerve (e.g. desferoxamine, chloroquine/hydrochloroquine, chlorpromazine, phenothiazines, tamoxifen, nicotinic acid, and ethambutol)
• Additional eye disease in the study eye that could compromise best corrected VA (BCVA). Significant visual field loss, uncontrolled glaucoma (IOP>24), clinically significant diabetic maculopathy, history of ischemic optic neuropathy or retinal vascular occlusion, symptomatic vitreomacular traction, or genetic disorders such as retinitis pigmentosa; history of high myopia > 8 diopters in the study eye. Anterior segment and vitreous abnormalities in the study eye that would preclude adequate observation with SD-OCT and OCTA Further exclusion criteria apply

Where it is running

• California Retina Consultants — Bakersfield, California, United States
• Retinal Consultants Medical Group — Sacramento, California, United States
• Bay Area Retina Associates - Walnut Creek — Walnut Creek, California, United States
• Cumberland Valley Retina Consultants, PC. — Hagerstown, Maryland, United States
• Meridian Clinical Research, LLC — Cincinnati, Ohio, United States
• Erie Retina Research, LLC — Erie, Pennsylvania, United States
• Mid Atlantic Retina — Philadelphia, Pennsylvania, United States
• Austin Research Center for Retina, PLLC — Austin, Texas, United States
• Austin Clinical Research, LLC — Austin, Texas, United States
• Retina Consultants of Texas — Bellaire, Texas, United States
• Retina Consultants of Texas — The Woodlands, Texas, United States
• Adelaide Eye and Retina Centre — Adelaide, South Australia, Australia
• Hobart Eye Surgeons — Hobart, Tasmania, Australia
• Riga East University Hospital — Riga, Latvia
• Leids Universitair Medisch Centrum (LUMC) — Leiden, Netherlands
• Hospital Dos de Maig — Barcelona, Spain
• Hospital Vall d'Hebron — Barcelona, Spain
• Hospital Clínico San Carlos — Madrid, Spain
• Hospital Miguel Servet — Zaragoza, Spain
• Bristol Eye Hospital — Bristol, United Kingdom
• Royal Liverpool University Hospital — Liverpool, United Kingdom
• Moorfields Eye Hospital — London, United Kingdom
• Central Middlesex Hospital — London, United Kingdom
• Oxford Eye Hospital — Oxford, United Kingdom
• Sunderland Eye Infirmary — Sunderland, United Kingdom

Full record on ClinicalTrials.gov

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