Neurobiological and Psychological Maintenance Mechanisms Associated With Anticipatory Reward in Bulimia Nervosa
Recruiting now
Conditions studied: Bulimia Nervosa
In brief
The purpose of this investigation is to identify the potentially crucial role of anticipatory reward mechanisms maintaining bulimic behavior (i.e., binge eating and purging) in bulimia nervosa (BN). The research will investigate neural and psychological anticipatory processes in BN, both in the scanner and the natural environment.
Key facts
- Study ID
- NCT04917068
- Run by
- University of Minnesota
- People needed
- 100
- Starts
- 2022-04-01
- Expected to finish
- 2026-11-30
- Last updated by the study team
- 2026-01-08
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Bulimia nervosa (BN) and healthy control (HC) groups:
- Right-handed
- Ability to read and speak in English
- BN group only:
- Eating Disorder Examination (EDE) diagnosis of BN (i.e., at least one objective bulimic episode and one self-induced vomiting episode per week for at three months) with binge episodes always accompanied by self-induced vomiting
- Stable dose for at least 6 weeks of any recent changes in medication impacting mood, appetite, or weight
- HC group only:
- No binge eating or purging episodes for the past three months on the EDE
- No current or past history of an eating disorder as diagnosed by Structured Clinical Interview for DSM-5 Disorders
You may not qualify if…
- History of gastric bypass surgery
- Medical condition acutely affecting eating behavior and/or weight (i.e., pregnancy, lactation, thyroid disease)
- Current medical or psychiatric instability (i.e., hospitalization required in the past three months)
- Lifetime history of psychosis or bipolar disorder
- History of neurological disorder or injury (i.e., stoke, head injury with >10 minutes loss of consciousness)
- Current substance use disorder
- BMI less than 19 kg/m\^2
- Acute suicidality requiring hospitalization
- fMRI exclusions as specifiedd by the Center for Magnetic Resonance Research
- Food allergy that cannot be accommodated through substitutions to the laboratory test snack
Where it is running
- University of Minnesota — Minneapolis, Minnesota, United States (enrolling)
Full record on ClinicalTrials.gov
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