A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer
Stopped early · Phase 2
Conditions studied: Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma, Triple Negative Breast Cancer, Non-Small Cell Lung Cancer, Oropharynx Squamous Cell Carcinoma
In brief
The goal of this study is to learn if giving cemiplimab and vidutolimod together could be effective in treating advanced cancer. The main questions it aims to answer are: * How many participants' cancers respond to vidutolimod together with cemiplimab? * Is vidutolimod together with cemiplimab safe and well-tolerated? * How well does vidutolimod together with cemiplimab treat participants' cancer? Participants will receive trial treatment for up to 2 years. 30 days after stopping treatment, participants will have a follow-up visit. After that visit, the trial staff will continue to follow up with participants about every 3 months, until the trial ends.
Key facts
- Study ID
- NCT04916002
- Run by
- Regeneron Pharmaceuticals
- People needed
- 77
- Starts
- 2021-11-30
- Expected to finish
- 2024-10-31
- Last updated by the study team
- 2026-06-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama — Birmingham, Alabama, United States
- City of Hope — Duarte, California, United States
- UC San Diego Moores Cancer Center — La Jolla, California, United States
- University of California — Los Angeles, California, United States
- GenesisCare USA — Jacksonville, Florida, United States
- Orlando Health Cancer Institute — Orlando, Florida, United States
- University of Iowa — Iowa City, Iowa, United States
- Norton Cancer Institute — Louisville, Kentucky, United States
- VA Maryland Health Care System — Baltimore, Maryland, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Karmanos Cancer Institute — Detroit, Michigan, United States
- Dartmouth Clinical Trial Office — Lebanon, New Hampshire, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- East Carolina University — Greenville, North Carolina, United States
- Ohio State University — Columbus, Ohio, United States
- OU Health Stephenson Cancer Center — Oklahoma City, Oklahoma, United States
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
- Oncology Consultants — Houston, Texas, United States
- University of Utah Huntsman Cancer Center — Salt Lake City, Utah, United States
- University of Washington — Seattle, Washington, United States
- St. Vincent's Hospital — Darlinghurst, New South Wales, Australia
- Princess Alexandra Hospital — Woolloongabba, Queensland, Australia
- Peter MacCallum Cancer Centre (PMCC) and The Royal Melbourne Hospital — Melbourne, Victoria, Australia
- Fiona Stanley Hospital — Murdoch, Western Australia, Australia
Full record on ClinicalTrials.gov
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