All-extremity Exercise During Breast Cancer Chemotherapy

Recruiting now · Not applicable

Conditions studied: Breast Cancer

In brief

Currently, there are 3.5 million breast cancer survivors in the United States and this number is expected to increase dramatically. The proposed research will examine whether a novel exercise intervention for breast cancer patients who are undergoing chemotherapy protects against cardiovascular dysfunction. Findings may have implications for cardiovascular disease prevention in this population.

Key facts

Study ID

NCT04914663

Run by

University of Florida

People needed

68

Starts

2024-04-05

Expected to finish

2027-01-31

Last updated by the study team

2025-10-01

Who can join

Age: 18 and older, up to 85. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Active diagnosis of primary invasive non-metastatic breast cancer, stages I-III
• Female
• 18 to 85 years of age
• Scheduled to initiate neoadjuvant or adjuvant chemotherapy (anthracycline, alkylating agent and/or taxane)
• Absence of contraindications to exercise
• Study clinician approval
• Able to give consent
• Informed consent obtained from the subject and documentation of subject agreement to comply with study-related process

You may not qualify if…

• Do not meet inclusion criteria
• Receiving targeted therapies (CDK4/6 or PARP inhibitors)
• Receiving radiation therapy concurrent with chemotherapy
• Lymphedema stage ≥ 2 prior to study enrollment
• Any relevant cardiovascular diseases (stroke, heart failure, myocardial ischemia during maximal graded exercise test, myocardial infarction, angina pectoris, coronary artery bypass surgery or angioplasty or coronary stent)
• Current participation in other experimental interventions that may confound interpretation of study findings (e.g., dietary intervention for weight loss)

Where it is running

• Integrative Cardiovasculal Physiology Laboratory, University of Florida — Gainesville, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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