Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries

Recruiting now · Phase 4

Conditions studied: Hypotension Drug-Induced

In brief

Objectives: To compare the safety and efficacy of oral atenolol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during nasal surgeries. Background: Mucosal bleeding is the most frequent complication with nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, increases operation time, and consequently increases blood loss. There are several pharmacological and non-pharmacological techniques for the appropriate control of intraoperative bleeding. Patients and Methods: This was a prospective, randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received oral atenolol, and group M, received oral metoprolol.

Key facts

Study ID

NCT04914234

Run by

Damanhour Teaching Hospital

People needed

60

Starts

2025-08-01

Expected to finish

2026-01-30

Last updated by the study team

2025-08-21

Who can join

Age: 21 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• American Society of Anesthesiologists (ASA) physical status ≤ II
• Age from 21 to 50 years

You may not qualify if…

• ASA physical status > II
• Age < 21 years or > 50 years
• Pregnant women
• Breastfeeding
• Bronchial asthma
• Chronic obstructive pulmonary disease
• Diabetes Mellitus
• Hypertension
• Ischemic heart disease
• Rheumatic heart disease
• Heart failure
• Heart block
• Sick sinus syndrome
• Sinus bradycardia
• Chronic hypotension
• Anemia (Hb < 10 g/dl)
• Renal or hepatic dysfunction
• Central nervous system disease
• Allergic fungal sinusitis
• Patients on beta-blockers
• Alcohol or drug abuse
• Anticoagulation therapy,
• Bleeding diathesis
• Agents influencing autonomic nervous system
• Allergy to the study drugs

Where it is running

• Damanhour Teaching Hospital — Damanhūr, El-Beheira, Egypt (enrolling)

Full record on ClinicalTrials.gov

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