Efficacy of Preventive Ketamine on Postoperative Pain

Recruiting now · Phase 4

Conditions studied: Postoperative Pain

In brief

* Although bariatric surgery is mainly performed laparoscopically, analgesic optimization is still essential to reduce complications and to improve the patients' comfort. In laparoscopic sleeve gastrectomy, the intraoperative peritoneal instillation of bupivacaine hydrochloride (30 ml, 0.25%) was known to be safe and effective in reducing postoperative pain, nausea, and vomiting. * Furthermore, usage of ketamine both as a pre and post-operative pain management is well established. Ketamine can be used solely or in combination with other co-adjuvant drugs, increasing their efficacy. Many therapeutic properties of ketamine have been attributed to its antagonism mechanism to N-Methyl-D-aspartate receptors.

Key facts

Study ID

NCT04908579

Run by

Ain Shams University

People needed

90

Starts

2021-06-15

Expected to finish

2026-09-30

Last updated by the study team

2026-07-07

Who can join

Age: 21 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• - Body mass index > 35 and < 60 kg/m2
• Either medically free or with well controlled hypertension and/or diabetes.

You may not qualify if…

• - Patient's refusal to participate in the study
• BMI > 60 kg/m2.
• Age less than 21 years.
• Patients with severe systemic disease which is not life-threatening.
• Patients on antipsychotics, antidepressants and/or corticosteroids.
• Patients with history of obstructive sleep apnea.
• Allergic reaction to any of the study medications.

Where it is running

• Ain-Shams University Hospitals — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

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